Evidence map›Paper›PMID 35524071›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2022

ISSLS Prize in Bioengineering Science 2022: low rate cyclic loading as a therapeutic strategy for intervertebral disc regeneration.

Elizabeth A Capogna, Emma Brown, Evan Walrath, William Furst, Qing Dong, Chao-Ming Zhou, Sarah E Gullbrand, Nam V Vo, Gwendolyn A Sowa, Eric H Ledet

Abstract read
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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Running is associated with intervertebral disc adaptations: a pre-planned secondary analysis of the ASTEROID randomised controlled trial.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Trial
  2. The pivotal role and intervention strategies of BMAL1 mediated circadian clock dysregulation in intervertebral disc degeneration.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Elizabeth A CapognaDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA.
Emma BrownDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA.
Evan WalrathDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA.
William FurstDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA.
Qing DongUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Chao-Ming ZhouUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Sarah E GullbrandUniversity of Pennsylvania, Philadelphia, PA, USA.
Nam V VoUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Gwendolyn A SowaUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Eric H LedetDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 1108 th Street, JEC 7044, Troy, NY, 12180, USA. ledete@rpi.edu.ORCID 0000-0002-0929-0185
Rensselaer Polytechnic Institute · USUniversity of Pittsburgh Medical Center · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe intervertebral disc degenerates with age and has a poor propensity for regeneration. Small molecule transport plays a key role in long-term degradation and repair. Convection (bulk flow), induced by low rate cyclic loading of the intervertebral disc, has been shown to increase transport of small molecules. However, the potential therapeutic benefit of low rate cyclic loading on degenerated discs has not been described. The purpose of this study was to determine if a sustained (daily) low rate cyclic loading regimen could slow, arrest, or reverse intervertebral disc degeneration in the rabbit lumbar spine.

methodsFifty-six New Zealand white rabbits (>12 months old) were designated as either Control (no disc puncture), 8D (disc puncture followed by 8 weeks of degeneration), 16D (disc puncture followed by 16 weeks of degeneration), or Therapy (disc puncture followed by 8 weeks of degeneration and then 8 weeks of daily low rate cyclic loading). Specimens were evaluated by T2 mapping, Pfirrmann scale grading, nucleus volume, disc height index, disc morphology and structure, and proteoglycan content.

resultsIn every metric, mean values for the Therapy group fell between Controls and 8D animals. These results suggest that sustained low rate cyclic loading had a therapeutic effect on the already degenerated disc and the regimen promoted signs of regeneration. If these results translate clinically, this approach could fulfil a significant clinical need by providing a means of non-invasively treating intervertebral disc degeneration.

Indexed as

Awards and PrizesIntervertebral DiscIntervertebral Disc DegenerationAnimalsBioengineeringDisease Models, AnimalHumansRabbitsRegenerationBiomechanicsCyclic loadingIntervertebral discRegenerationSpineTransport

Identifiers

PMID35524071
OpenAlexW4229074546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.