ArticleMethods in molecular biology (Clifton, N.J.)2022
Investigating Fungal Biosynthetic Pathways Using Heterologous Gene Expression: Aspergillus nidulans as a Heterologous Host.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Metabolic reprogramming of abscisic acid-producing strainSynthetic and systems biotechnology · 2026Article
- Propellane Alkaloid Biosynthesis and Total Synthesis via Interrupted Reaction Pathways.ACS central science · 2026Article
- Biosynthesis of the α-D-mannosidase inhibitor (-)-Swainsonine.Nature chemical biology · 2026Article
- Genome-guided discovery of clavaic acid, a decalin-containing polyketide encoded by a LovB-like polyketide synthase.Journal of industrial microbiology & biotechnology · 2026Article
- Genome Mining and Heterologous Reconstitution of a PKS-NRPS Gene Cluster fromJournal of fungi (Basel, Switzerland) · 2025Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Genome Mining-Guided Discovery of Two New Depsides fromMarine drugs · 2025Article
- Microbial biosynthesis of rare cannabinoids.Journal of industrial microbiology & biotechnology · 2024Article
- Biosynthesis of iron-chelating terramides A-C and their role in Aspergillus terreus infection.Communications chemistry · 2024Article
- Extending the Structural Diversity of Labdane Diterpenoids from Marine-Derived FungusMarine drugs · 2023Article
- Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure.Journal of the American Chemical Society · 2023Article
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2 authors.
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Abstract
Fungal natural products encompass an important source of pharmaceutically relevant molecules. Heterologous expression of biosynthetic pathways in chassis strains enables the discovery of new secondary metabolites and characterization of pathway enzymes. In our laboratory, biosynthetic genes in a clustered pathway have been refactored in engineered heterologous hosts such as Aspergillus nidulans. Here we describe the assembly of heterologous expression vectors, transformation into A. nidulans, and detection of new compounds in the transformant strains.
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