ReviewNature reviews. Urology2022
Evolution of the World Health Organization semen analysis manual: where are we?
Review in Nature reviews. Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 55 citations in OpenAlex.
- Redefining Cryopreservation Media: L-Methionine Boosts Post-Thaw Sperm Quality Across Fertility Status.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- The genomic era of "idiopathic" male infertility: why comprehensive andrological evaluation matters more than ever.Journal of assisted reproduction and genetics · 2026Article
- Sperm DNA fragmentation: how to test, when to test, and what to do with abnormal results-a pragmatic mini-review for clinical practice.Human reproduction (Oxford, England) · 2026Review
- Double-stranded sperm DNA fragmentation measured with neutral comet assay as a predictor of IVF outcomes: evidence from three European clinics in a multi-centred prospective study.Human reproduction (Oxford, England) · 2026Article
- Artificial intelligence in infertility treatment: Applications, challenges, and future directions: A narrative review.International journal of reproductive biomedicine · 2026Review
- Effect of telomere length and related gene polymorphism in signaling pathway on semen quality.Scientific reports · 2026Article
- Association of sperm DNA fragmentation with abstinence duration, seminal oxidative stress and age: a call to consider abstinence in andrological diagnostics.Frontiers in urology · 2026Article
- Efficacy of acupuncture in the treatment of asthenospermia in obese men: study protocol for a randomized control trial.Frontiers in medicine · 2026Article
- Bridging the Gap: How environmental exposures compromise male fertility and clinical Outlook.Current research in toxicology · 2026Review
- Photobiomodulation Improves Testicular Structure and Antioxidant Defense in a Rat Model of Torsion/Detorsion.Journal of lasers in medical sciences · 2026Article
- Male infertility.Systems biology in reproductive medicine · 2025Review
- Evaluating the effect of smoking and its cessation on semen parameters.Reproduction & fertility · 2025Article
- Unlocking the power of semen analysis in primary health care - a path to men's health and lifestyle transformation.Nature reviews. Urology · 2025Review
- Toward predictive andrology: integrating basic semen analysis mitochondrial deoxyribonucleic acid and artificial intelligence to forecast reproductive outcomes.F&S reports · 2025Article
- Glycerol Kinase 2 as a Metabolic Sentinel for Human Sperm Motility and Male Fertility.Biomolecules · 2025Review
- The Relationship Between Sperm Midpiece Details and DNA Fragmentation in Human Sperm.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review).Molecular medicine reports · 2025Review
- High-frequency ultrasound shear wave dispersion imaging for male infertility: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Weight Loss as Therapeutic Option to Restore Fertility in Obese Men: A Meta-Analytic Study.The world journal of men's health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WHO (World Health Organization) manuals provide state-of-the-art guidance on how a semen analysis should be carried out. The much anticipated sixth edition of the WHO semen analysis manual has been released 10 years after its previous version and includes essential updates, such as new reference standards for semen volume and microscopic sperm characteristics of recent fathers. A well-conducted semen analysis remains an essential foundation of the infertility evaluation process and affects patient referral, diagnosis and treatment. However, a male infertility work-up primarily based on routine semen analysis does not provide men with an optimal fertility pathway; the primary reasons for routine semen analysis inadequacy in this context include its low predictive value for natural and assisted conception success, its inability to detect sperm DNA and epigenetic deficiencies that might negatively affect embryo development, implantation and offspring well-being, and the substantial overlap between semen parameters of fertile and subfertile individuals. Ideally, a full andrological assessment should be carried out by reproductive urologists in all men dealing with couple infertility and should include a detailed history analysis, physical examination, semen analysis, endocrine assessment and other tests as needed. Only through a complete male infertility work-up will relevant underlying medical and infertility conditions be revealed and potentially treated or alleviated. The ultimate goals of a comprehensive andrological assessment are to positively influence overall male health, pregnancy prospects and offspring well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.