Evidence map›Paper›PMID 35523848›Full record

SynthesisBone marrow transplantation2022

Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.

Rachel Phelan, Annie Im, Rebecca L Hunter, Yoshihiro Inamoto, Maria Teresa Lupo-Stanghellini, Alicia Rovo, Sherif M Badawy, Linda Burns, Hesham Eissa, Hemant S Murthy and 45 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Article
  4. Frontiers in genetics · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Rachel Phelan *CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. rphelan@mcw.edu.ORCID http://orcid.org/0000-0001-5252-9991
Annie Im *University of Pittsburgh/UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Rebecca L HunterDivision of Hematology, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Yoshihiro InamotoDivision of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Maria Teresa Lupo-StanghelliniHematology and Bone Marrow Transplantation Unit, IRCC San Raffaele Scientific Institute, Milano, Italy.
Alicia RovoDepartment of Hematology and Central Hematology Laboratory, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-7757-4753
Sherif M BadawyDivision of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Linda BurnsCIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0003-1341-4424
Hesham EissaDepartment of Pediatrics, Center for Cancer and Blood Disorders, University of Colorado School of Medicine, Aurora, CO, USA.
Hemant S MurthyDivision of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA.
Pinki PrasadLouisiana State University Health Sciences Center/Children's Hospital of New Orleans, Department of Pediatrics, New Orleans, LA, USA.ORCID http://orcid.org/0000-0003-4759-489X
Akshay SharmaDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3281-2081
Elizabeth SuelzerMedical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-1809-8080
Vaibhav AgrawalDivision of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.
Mahmoud AljurfDepartment of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0003-3942-7370
Karen BakerDuke University Medical Center, Durham, NC, USA.
Grzegorz W BasakUniversity Clinical Centre, Medical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0003-3858-8180
David BuchbinderDivision of Pediatric Hematology, Children's Hospital of Orange County, Orange, CA, USA.
Zachariah DeFilippHematopoietic Cell Transplant and Cellular Therapy Program, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7994-8974
Lana Desnica GrkovicUniversity Hospital Centre Zagreb, Zagreb, Croatia.
Ajoy DiasBeth Israel Deaconess Medical Center, Boston, MA, USA.
Hermann EinseleUniversitätsklinikum Würzburg, Department of Internal Medicine II, Würzburg, Germany.
Michael L EisenbergDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Narendranath EpperlaDivision of Hematology, Department of Medicine, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-8216-3457
Nosha FarhadfarDivision of Hematology/Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Arthur FlatauAssociation of Cancer Online Resources, Association of Cancer Online Resources, Austin, TX, USA.
Robert Peter GaleHaematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
Hildegard GreinixMedical University Graz, Division of Hematology, Graz, Austria.
Betty K HamiltonBlood & Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-1252-6539
Shahrukh HashmiDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Peiman HemattiDivision of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin, Madison, WI, USA.
Kareem JamaniTom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Dipnarine MaharajSouth Florida Bone Marrow Stem Cell Transplant Institute, Boynton Beach, FL, USA.
John MurrayThe Christie NHS Foundation Trust, Manchester, UK.
Seema NaikDivision Hematology and Oncology, Department of Medicine, Penn State Cancer Institute, Milton Hershey Medical Center, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-9859-151X
Sunita NathanSection of Bone Marrow Transplant and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7920-4265
Steven PavleticImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Zinaida PericUniversity Hospital Centre Zagreb and Medical School University of Zagreb, Zagreb, Croatia.ORCID http://orcid.org/0000-0001-9458-8025
Drazen PulanicUniversity Hospital Centre Zagreb and Medical School University of Zagreb, Zagreb, Croatia.
Richard RossThe University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-9222-9678
Andrea SaloniaUniversity Vita-Salute San Raffaele, Milan, Italy.
Isabel Sanchez-OrtegaInstitut Catala d'Oncologia, Barcelona, Spain.
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Tal SchechterDivision of Pediatric Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Ami J ShahDivision of Hematology/ Oncology/ Stem Cell Transplantation and Regenerative Medicine, Lucile Packard Children's Hospital, Stanford School of Medicine, Palo Alto, CA, USA.
Stephanie M SmithDivision of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
John A SnowdenThe University of Sheffield, Sheffield, UK.
Amir SteinbergWestchester Medical Center, Valhalla, NY, USA.
Douglas TremblayDivision of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-2584-6953
Sarah C VijDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Lauren WalkerDepartment of Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0001-7015-3190
Jean A YaredBlood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5346-6299
Hélène Schoemans *Department of Hematology, University Hospitals Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7568-8239
André Tichelli *University Hospital Basel, Basel, Switzerland.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationAdultBone MarrowDisease ProgressionHumansMaleQuality of LifeTransplant Recipients

Identifiers

PMID35523848
PMCPMC10316716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.