Evidence map›Paper›PMID 35523776›Full record

ArticleTranslational psychiatry2022

Longitudinal trajectory of response to electroconvulsive therapy associated with transient immune response & white matter alteration post-stimulation.

Blake Andreou, Benjamin Reid, Amanda E Lyall, Suheyla Cetin-Karayumak, Antoni Kubicki, Randall Espinoza, Jennifer Kruse, Katherine L Narr, Marek Kubicki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Blake Andreou *Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin Reid *Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8049-516X
Suheyla Cetin-KarayumakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3315-5821
Antoni KubickiAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.
Randall EspinozaJane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID 0000-0003-2895-4212
Jennifer KruseJane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID 0000-0003-0628-3921
Katherine L NarrJane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.
Marek KubickiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kubicki@bwh.harvard.edu.ORCID 0000-0002-3989-8212
Brigham and Women's Hospital · USBrain Mapping Foundation · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SKUniversity of California, Los Angeles · US

Funding

Perturbation of the treatment resistant depression connectome by fast-acting therapiesU01MH110008 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2016 to 2019
$5.5M
Imaging biomarkers of ECT response in major depressive disorderR01MH092301 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2011 to 2015
$4.0M
Diffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8M
Mentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945k
Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET StudyK01MH115247 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI LYALL, AMANDA ELLIS · 2018 to 2022
$889k
Depression Response to Fast-Acting Treatments: Inflammation and Reward MechanismsK23MH116127 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KRUSE, JENNIFER · 2018 to 2021
$790k
Imaging White Matter Maturation and Genetic High Risk for SchizophreniaR03MH110745 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI LYALL, AMANDA ELLIS · 2016 to 2017
$178k
NIMH NIH HHS K01 MH115247NIMH NIH HHS K23 MH116127NIMH NIH HHS K24 MH110807NIMH NIH HHS MH092301NIMH NIH HHS MH110008NIMH NIH HHS MH116127NIMH NIH HHS R01 MH092301NIMH NIH HHS R01 MH102377NIMH NIH HHS R03 MH110745NIMH NIH HHS U01 MH110008
6 · The paper itself

Abstract

Research suggests electroconvulsive therapy (ECT) induces an acute neuroinflammatory response and changes in white matter (WM) structural connectivity. However, whether these processes are related, either to each other or to eventual treatment outcomes, has yet to be determined. We examined the relationship between levels of peripheral pro-inflammatory cytokines and diffusion imaging-indexed changes in WM microstructure in individuals with treatment-resistant depression (TRD) who underwent ECT. Forty-two patients were assessed at baseline, after their second ECT (T2), and after completion of ECT (T3). A Montgomery Åsberg Depression Rating Scale improvement of >50% post-ECT defined ECT-responders (n = 19) from non-responders (n = 23). Thirty-four controls were also examined. Tissue-specific fractional anisotropy (FAt) was estimated using diffusion imaging data and the Free-Water method in 17 WM tracts. Inflammatory panels were evaluated from peripheral blood. Cytokines were examined to characterize the association between potential ECT-induced changes in an inflammatory state and WM microstructure. Longitudinal trajectories of both measures were also examined separately for ECT-responders and non-responders. Patients exhibited elevated Interleukin-8 (IL-8) levels at baseline compared to controls. In patients, correlations between IL-8 and FAt changes from baseline to T2 were significant in the positive direction in the right superior longitudinal fasciculus (R-SLF) and right cingulum (R-CB) (p

Indexed as

Electroconvulsive TherapyWhite MatterCytokinesHumansImmunityInterleukin-8CytokinesInterleukin-8

Identifiers

PMID35523776
PMCPMC9076613
OpenAlexW4229044009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.