Evidence map›Paper›PMID 35523715›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2022

Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis.

Don B Sanders, Ashley R Deschamp, Joseph E Hatch, James E Slaven, Netsanet Gebregziabher, Mariette Kemner-van de Corput, Harm A W M Tiddens, Tim Rosenow, Gregory A Storch, Graham L Hall and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. The association between gut microbiome and growth in infants with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  2. Article
  3. A year in review (2022): Modulators and COVID19, the story goes on….Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Don B SandersDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: dbsand@iu.edu.
Ashley R DeschampDepartment of Pediatrics, University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, NE, USA.
Joseph E HatchDepartment of Pediatrics, UNC Children's, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
James E SlavenDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Netsanet GebregziabherDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Mariette Kemner-van de CorputDepartment of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medial Center Rotterdam, Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC - Sophia Children's Hospital, University Medial Center Rotterdam, Netherlands.
Harm A W M TiddensDepartment of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medial Center Rotterdam, Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC - Sophia Children's Hospital, University Medial Center Rotterdam, Netherlands.
Tim RosenowThe Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Nedlands, Western Australia; Children's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute and School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.
Gregory A StorchDepartment of Pediatrics, Washington University, St. Louis Children's Hospital, St. Louis, MO, USA.
Graham L HallChildren's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute and School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.
Stephen M StickDepartment of Pediatrics, University of Western Australia, Telethon Kids Institute, Perth, Australia.
Sarath RanganathanDepartment of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
Thomas W FerkolDepartment of Pediatrics, Washington University, St. Louis Children's Hospital, St. Louis, MO, USA.
Stephanie D DavisDepartment of Pediatrics, UNC Children's, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Indiana University School of MedicineThe Kids Research Institute Australia · AUErasmus MC - Sophia Children’s Hospital · NLSt. Louis Children's Hospital · USUniversity of North Carolina at Chapel Hill · USChildren's Hospital & Medical Center · USRoyal Children's Hospital · AU

Funding

Viral Pathogenesis of Early Cystic Fibrosis Lung DiseaseR01HL116211 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DAVIS, STEPHANIE DUGGINS, FERKOL, THOMAS W · 2012 to 2015
$2.2M
NHLBI NIH HHS R01 HL116211
6 · The paper itself

Abstract

backgroundInfants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF.

methodsInfants with CF were enrolled before 4 months of age. Multiplex PCR assays were performed on nasal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent CT imaging at approximately 12 months of age. Associations between Perth-Rotterdam Annotated Grid Morphometric Analysis for CF (PRAGMA-CF) CT scores and respiratory viruses and symptoms were assessed with Spearman correlation coefficients.

resultsSixty infants were included for analysis. Human rhinovirus was the most common virus detected, on 28% of tested nasal swabs and in 85% of participants. The median (IQR) extent of lung fields that was healthy based on PRAGMA-CF was 98.7 (0.8)%. There were no associations between PRAGMA-CF and age at first virus, or detection of any virus, including rhinovirus, respiratory syncytial virus, or parainfluenza. The extent of airway wall thickening was associated with ever having wheezed (ρ = 0.31, p = 0.02) and number of encounters with cough (ρ = 0.25, p = 0.0495).

conclusionsInfants with CF had minimal structural lung disease. We did not find an association between respiratory viruses and CT abnormalities. Wheezing and frequency of cough were associated with early structural changes.

Indexed as

Cystic FibrosisRespiratory Tract InfectionsVirus DiseasesVirusesCoughHumansInfantLungChest computed tomographyCystic fibrosisNewborn screeningRespiratory infectionViruses

Identifiers

PMID35523715
PMCPMC10564322
OpenAlexW4229335036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.