Evidence map›Paper›PMID 35523621›Full record

ArticleUltrasound in medicine & biology2022

Blood Flow Changes Associated with Spinal Cord Injury Assessed by Non-linear Doppler Contrast-Enhanced Ultrasound.

Matthew Bruce, Dane DeWees, Jennifer N Harmon, Lindsay Cates, Zin Z Khaing, Christoph P Hofstetter

Abstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Transverse Velocity Spectral Estimation Method for Ultrafast Ultrasound Doppler Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  10. The Brain and Spinal Microvasculature in Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Review
  11. FlowMorph: Morphological Segmentation of Ultrasound-Monitored Spinal Cord Microcirculation.IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew BruceApplied Physics Laboratory/Center for Industrial and Medical Ultrasound, University of Washington, Seattle, Washington, USA. Electronic address: mbruce@uw.edu.
Dane DeWeesDepartment of Neurosurgery, University of Washington, Seattle, Washington, USA.
Jennifer N HarmonDepartment of Neurosurgery, University of Washington, Seattle, Washington, USA.
Lindsay CatesDepartment of Neurosurgery, University of Washington, Seattle, Washington, USA.
Zin Z KhaingDepartment of Neurosurgery, University of Washington, Seattle, Washington, USA.
Christoph P HofstetterDepartment of Neurosurgery, University of Washington, Seattle, Washington, USA.

Funding

Development of Contrast Enhanced Functional Ultrasound Imaging to Monitor Induced Neuroplasticity in Chronic Spinal Cord InjuryF32HD107806 · NICHD · UNIVERSITY OF WASHINGTON · PI HARMON, JENNIFER · 2022 to 2023
$142k
NICHD NIH HHS F32 HD107806
6 · The paper itself

Abstract

Contrast-enhanced ultrasound (CEUS) is clinically used to image the microcirculation at lower imaging frequencies (<2 MHz). Recently, plane-wave acquisitions and Doppler processing have revealed improved microbubble sensitivity, enabling CEUS use at higher frequencies (15 MHz) and the ability to image simultaneously blood flow in the micro- and macrocirculations. We used this approach to assess acute and chronic blood flow changes within contused spinal cord in a rodent spinal cord injury model. Immediately after spinal cord injury, we found significant differences in perfusion deficit between moderate and severe injuries (1.73 ± 0.1 mm

Indexed as

ContusionsSpinal Cord InjuriesAnimalsContrast MediaDisease Models, AnimalUltrasonographyContrast MediaDopplerMicrobubblesSpinal cord injuryUltrasound contrast agents

Identifiers

PMID35523621
PMCPMC9704544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.