Evidence map›Paper›PMID 35523590›Full record

ArticleJournal of neurochemistry2022

Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt-1 knockout mice.

Larissa Erben, Jacqueline P Welday, Marie E Cronin, Ricardo Murphy, Miguel Skirzewski, Detlef Vullhorst, Steven L Carroll, Andres Buonanno

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Larissa ErbenSection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0002-5792-9318
Jacqueline P WeldaySection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0003-0151-7418
Marie E CroninSection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0002-7315-9624
Ricardo MurphySection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0002-3452-3438
Miguel SkirzewskiSection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0002-0980-0878
Detlef VullhorstSection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0002-7947-8044
Steven L CarrollDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0001-6714-4373
Andres BuonannoSection on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland, USA.ORCID 0000-0003-4651-9134
National Institutes of Health · USMedical University of South Carolina · US

Funding

Neuregulin-ErbB Signaling in Neuronal Development and Psychiatric DisordersZIAHD000711 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BUONANNO, ANDRES · 2009 to 2024
$24.4M
TRANSCRIPTION REGULATION OF SYNAPSE-SPECIFIC GENES IN SKELETAL MUSCLEZ01HD000711 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BUONANNO, ANDRES · 1990 to 2008
$2.4M
Role of Neuregulin-1 in Schwann Cell NeoplasiaR01NS048353 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARROLL, STEVEN L. · 2004 to 2008
$1.3M
Intramural NIH HHS Z01 HD000711Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000711NINDS NIH HHS R01 NS048353
6 · The paper itself

Abstract

Neuregulins (NRGs) and their cognate neuronal receptor ERBB4, which is expressed in GABAergic and dopaminergic neurons, regulate numerous behaviors in rodents and have been identified as schizophrenia at-risk genes. ErbB4 transcripts are alternatively spliced to generate isoforms that either include (Cyt-1) or exclude (Cyt-2) exon 26, which encodes a cytoplasmic domain that imparts ErbB4 receptors the ability to signal via the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Although ErbB4 Cyt-1/2 isoforms have been studied in transfected cultured cells, their functions in vivo remain unknown. Here, we generated ErbB4-floxed (ErbB4-Cyt1

Indexed as

ErbB ReceptorsPhosphatidylinositol 3-KinasesReceptor, ErbB-4AnimalsDopamineMiceMice, KnockoutProtein IsoformsDopamineErbb4 protein, mouseErbB ReceptorsPhosphatidylinositol 3-KinasesProtein IsoformsReceptor, ErbB-4

Identifiers

PMID35523590
PMCPMC9149141
OpenAlexW4229053559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.