Evidence map›Paper›PMID 35523505›Full record

ArticleBMJ open2022

Effects of 3 months of multi-nutrient supplementation on the immune system and muscle and respiratory function of older adults in aged care (The Pomerium Study): protocol for a randomised controlled trial.

Ahmed Al Saedi, Ben Kirk, Sandra Iuliano, Jesse Zanker, Sara Vogrin, Lata Jayaram, Shane Thomas, Christine Golding, Diana Navarro-Perez, Petra Marusic and 3 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ahmed Al SaediMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Ben KirkMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Sandra IulianoMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Jesse ZankerMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Sara VogrinMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Lata JayaramMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Shane ThomasAustralian Institute for Musculoskeletal Science (AIMSS), St Albans, Victoria, Australia.
Christine GoldingSchool of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Diana Navarro-PerezMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Petra MarusicAustralian Institute for Musculoskeletal Science (AIMSS), St Albans, Victoria, Australia.
Sean LengJohns Hopkins Center on Aging and Immune Remodeling, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ralph NananNepean Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Gustavo DuqueMedicine-Western Health, The University of Melbourne, Melbourne, Victoria, Australia gustavo.duque@unimelb.edu.au.ORCID 0000-0001-8126-0637
The University of Melbourne · AUAustralian Institute for Musculoskeletal Science · AUJohns Hopkins University · USThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionImmunosenescence leads to increased morbidity and mortality associated with viral infections and weaker vaccine responses. This has been well documented for seasonal influenza and the current pandemic with SARS-CoV-2 (COVID-19), which disproportionately impact older adults, particularly those in residential aged care facilities. Inadequate nutrient intakes associated with impaired immunity, respiratory and muscle function are likely to augment the effects of immunosenescence. In this study, we test whether the impact of inadequate nutrition can be reversed using multi-nutrient supplementation, consequently enhancing vaccine responses, reducing the risk of viral infections and improving respiratory and muscle function. METHODS AND ANALYSIS: The Pomerium Study is a 3-month, single-blind, randomised, controlled trial testing the effects of two daily servings of an oral multi-nutrient supplement (330 kcal, 20 g protein, 1.5 g calcium 3-hydroxy-3-methylbutyrate monohydrate (CaHMB), 449 mg calcium, 500 IU vitamin D ETHICS AND DISSEMINATION: This study was approved by Melbourne Health Human Research Ethics Committee (Ref No. HREC/73985/MH-2021, ERM Ref No. RMH73985, Melbourne Health Site Ref No. 2021.115). Written informed consent will be obtained from participants. Results will be published in peer-reviewed journals and made available to key aged care stakeholders, including providers, residents, and government bodies. TRIAL REGISTRATION NUMBER: ACTRN12621000420842.

Indexed as

COVID-19SARS-CoV-2AgedCalciumDietary SupplementsHand StrengthHumansImmune SystemMusclesNutrientsQuality of LifeRandomized Controlled Trials as TopicSingle-Blind MethodTreatment OutcomeCalciumNutrientsCOVID-19GERIATRIC MEDICINEIMMUNOLOGYINFECTIOUS DISEASESNUTRITION & DIETETICS

Identifiers

PMID35523505
PMCPMC9082724
OpenAlexW4229002451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.