Evidence map›Paper›PMID 35523138›Full record

ReviewCell stem cell2022

Engineering multiscale structural orders for high-fidelity embryoids and organoids.

Yue Shao, Jianping Fu

Abstract readReview
In one paragraph

Review in Cell stem cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Morphogenic colloids.Nature communications · 2026
    Article
  5. Review
  6. Mesoscale maladaptation in disease organoids.Disease models & mechanisms · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Bioengineering gradients for controlled embryo and organ modeling.Current opinion in biomedical engineering · 2025
    Article
  12. Article
  13. Article
  14. Primate amnion development.Development (Cambridge, England) · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yue ShaoInstitute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address: yshao@tsinghua.edu.cn.
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Acoustic Tweezing Cytometry for Efficient Neural DifferentiationR01GM143297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENG, CHERI X, FU, JIANPING · 2021 to 2024
$1.8M
Studying Origin of Human Primordial Germ Cells Using a Synthetic Stem Cell ModelR21HD100931 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING · 2020 to 2021
$422k
Synthetic microfluidic synthesis of spinal cord tissues from human pluripotent stem cellsR21NS113518 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING · 2019 to 2019
$422k
NICHD NIH HHS R21 HD100931NIGMS NIH HHS R01 GM143297NINDS NIH HHS R21 NS113518
6 · The paper itself

Abstract

Embryoids and organoids hold great promise for human biology and medicine. Herein, we discuss conceptual and technological frameworks useful for developing high-fidelity embryoids and organoids that display tissue- and organ-level phenotypes and functions, which are critically needed for decoding developmental programs and improving translational applications. Through dissecting the layers of inputs controlling mammalian embryogenesis, we review recent progress in reconstructing multiscale structural orders in embryoids and organoids. Bioengineering tools useful for multiscale, multimodal structural engineering of tissue- and organ-level cellular organization and microenvironment are also discussed to present integrative, bioengineering-directed approaches to achieve next-generation, high-fidelity embryoids and organoids.

Indexed as

BioengineeringOrganoidsAnimalsEmbryo, MammalianMammalsTissue Engineeringdevelopmental biologyembryoidmammalian embryogenesismechanobiologyorganoidstem cell engineering

Identifiers

PMID35523138
PMCPMC9097334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.