Evidence map›Paper›PMID 35523127›Full record

ArticleMolecular cell2022

Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival.

Dohun Kim, Gerta Hoxhaj

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dohun KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Gerta HoxhajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: gerta.hoxhaj@utsouthwestern.edu.
Children's Medical Center · US

Funding

Revealing the essential functions of mitochondrial NADPH and NADK2 for cell growth and proliferationR01GM143236 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HOXHAJ, GERTA N/A · 2021 to 2025
$1.8M
NIGMS NIH HHS R01 GM143236
6 · The paper itself

Abstract

Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods.

Indexed as

Drosophila ProteinsStarvationAdaptation, PsychologicalAnimalsCysteineDrosophilaMechanistic Target of Rapamycin Complex 1CysteineDrosophila ProteinsMechanistic Target of Rapamycin Complex 1

Identifiers

PMID35523127
OpenAlexW4229028595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.