Evidence map›Paper›PMID 35523034›Full record

ArticleCancer epidemiology2022

Joint association of statins and testosterone replacement therapy with cardiovascular disease among older men with prostate cancer: SEER-Medicare 2007-2015.

David S Lopez, Hyunkyoung Kim, Efstathia Polychronopoulou, Shaden Taha, Konstantinos K Tsilidis, Alejandro Villasante-Tezanos, M Kristen Peek, Syed Gilani, Mohit Khera, Jacques Baillargeon and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

David S LopezDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: davlopez@utmb.edu.
Hyunkyoung KimDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Efstathia PolychronopoulouDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Shaden TahaDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Alejandro Villasante-TezanosDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
M Kristen PeekDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Syed GilaniDivision of Cardiology, Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Mohit KheraScott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Jacques BaillargeonDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Yong-Fang KuoDeparment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
Steven CanfieldDivision of Urology, UTHealth McGovern Medical School, Houston, TX, USA.
The University of Texas Medical Branch at Galveston · USBaylor College of Medicine · USImperial College London · GBThe University of Texas Health Science Center at Houston · US

Funding

The Texas Resource Center on Minority Aging Research (RCMAR)P30AG059301 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kyriakos S Markides, Fernando Riosmena · 2018 to 2026
$5.2M
NIA NIH HHS P30 AG059301NIMHD NIH HHS L60 MD002942
6 · The paper itself

Abstract

backgroundUse of statins and testosterone replacement therapy (TTh) have been independently linked with prostate cancer (PCa) and cardiovascular diseases (CVD). However, there is a research gap about the joint association of statins and TTh with CVD among PCa survivors and a matched cancer-free cohort.

methodsIn SEER-Medicare 2007-2015 (N = 35,990 men), we identified 17,995 PCa survivors, and 17,995 age- and index-matched cancer-free men. Pre-diagnostic prescription of statins and TTh was ascertained for this analysis and examined in two matched cohorts. Weighted multivariable-adjusted conditional logistic regression models were used to evaluate the independent and joint associations of statins and TTh with CVD.

resultsWe found that independently statins (OR = 0.48, 95% CI: 0.44-0.53) and TTh (OR = 0.74, 95% CI: 0.0.61-0.90) were each inversely associated with CVD in the overall sample. TTh plus statins was inversely associated with CVD (OR = 0.50, 95% CI: 0.36-0.70, P

conclusionPre-diagnostic use of statins and TTh, independent or in combination, were inversely associated with CVD in the overall and cancer-free populations, but among PCa survivors it was mainly use of statins, not TTh. Greater reduced effects on CVD were observed with statins or in combination with statins, but not with TTh. Future studies need to confirm these associations among older men with aggressive PCa.

Indexed as

Cardiovascular DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsProstatic NeoplasmsAgedHumansMaleMedicareTestosteroneUnited StatesHydroxymethylglutaryl-CoA Reductase InhibitorsTestosteroneCardiovascular diseasesProstate cancer survivorsStatinsTestosterone

Identifiers

PMID35523034
PMCPMC9288979
OpenAlexW4229336651

What OpenQuestion holds

Texttitle and abstract
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.