Evidence map›Paper›PMID 35522818›Full record

ReviewAngewandte Chemie (International ed. in English)2022

Odorant Metabolism in Humans.

Nicole Kornbausch, Marcel W Debong, Andrea Buettner, Jean-Marie Heydel, Helene M Loos

Open access · hybridAbstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Past, Present, and Future of Human Chemical Communication Research.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
    Review
  8. Review
  9. Review
  10. Bitter Odorants and Odorous Bitters: Toxicity and Human TAS2R Targets.Journal of agricultural and food chemistry · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Odorant Metabolism in Humans.Angewandte Chemie (International ed. in English) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nicole KornbauschChair of Aroma and Smell Research, Department of Chemistry, Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestr. 9, 91054, Erlangen, Germany.ORCID 0000-0002-4850-5871
Marcel W DebongChair of Aroma and Smell Research, Department of Chemistry, Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestr. 9, 91054, Erlangen, Germany.ORCID 0000-0002-1565-9532
Andrea BuettnerChair of Aroma and Smell Research, Department of Chemistry, Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestr. 9, 91054, Erlangen, Germany.ORCID 0000-0002-6205-5125
Jean-Marie HeydelCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 7 bvd Jeanne d'Arc, 21000, Dijon, France.ORCID 0000-0002-6089-9922
Helene M LoosChair of Aroma and Smell Research, Department of Chemistry, Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestr. 9, 91054, Erlangen, Germany.ORCID 0000-0002-9112-5735
Friedrich-Alexander-Universität Erlangen-Nürnberg · DECentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odorants are relatively small molecules which are easily taken up and distributed in the human body. Despite their relevance in everyday life, however, only a limited amount of evidence about their metabolism, pathways, and bioactivities in the human body exists. With this Review, we aim to encourage future interdisciplinary research on the function and mechanisms of the biotransformation of odorants, involving different disciplines such as nutrition, medicine, biochemistry, chemistry, and sensory sciences. Starting with a general overview of the different ways of odorant uptake and enzymes involved in the metabolism of odorants, a more precise description of biotransformation processes and their function in the oral cavity, the nose, the lower respiratory tract (LRT), and the gastrointestinal tract (GIT) is given together with an overview of the different routes of odorant excretion. Finally, perspectives for future research are discussed.

Indexed as

OdorantsReceptors, OdorantBiological TransportHumansMouthSmellReceptors, OdorantBiotransformationEnzymesFlavorInhibitorsOlfaction

Identifiers

PMID35522818
PMCPMC9541901
OpenAlexW4229013498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.