ArticleScience advances2022
Frequency-dependent transition in power-law rheological behavior of living cells.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.Annual review of biomedical engineering · 2026Review
- Viscoelasticity analysis of coarse-grained cytoskeletal simulations with Cytosim and Cytocalc.Biophysical journal · 2026Article
- Usage of the adaptive quasi-linear viscoelastic model to predict load-unload, stress-relaxation, and sine load of porcine liver.Scientific reports · 2026Article
- Multiplexed Nanoscale Viscoelastic Mapping at Multiple Time Scales of Melanoma Cells as a Label-Free Cancer Biomarker.ACS nano · 2025Article
- Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects.Biophysical reviews · 2025Review
- Sonic-induced cellular vibrations unzip intertwined anther cone trichomes to trigger floral self-pollination and boost tomato fruit size.Horticulture research · 2025Article
- Cancer cells impact the microrheology of endothelial cells during physical contact or through paracrine signalling.Scientific reports · 2025Article
- Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells.Biophysical journal · 2025Article
- Multi-Zone Visco-Node-Pore Sensing: A Microfluidic Platform for Multi-Frequency Viscoelastic Phenotyping of Single Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Beyond stiffness: Multiscale viscoelastic features as biomechanical markers for assessing cell types and states.Biophysical journal · 2024Article
- Acoustic Wave-Induced Stroboscopic Optical Mechanotyping of Adherent Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Scaling-law mechanical marker for liver fibrosis diagnosis and drug screening through machine learning.Frontiers in bioengineering and biotechnology · 2024Article
- E-cadherin adhesion dynamics as revealed by an accelerated force ramp are dependent upon the presence of α-catenin.Biochemical and biophysical research communications · 2023Article
- Polymerization force-regulated actin filament-Arp2/3 complex interaction dominates self-adaptive cell migrations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication.Journal of pharmaceutical analysis · 2023Article
- Cytochalasin B Influences Cytoskeletal Organization and Osteogenic Potential of Human Wharton's Jelly Mesenchymal Stem Cells.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Mechanically robust bamboo node and its hierarchically fibrous structural design.National science review · 2023Article
- Network dynamics of the nonlinear power-law relaxation of cell cortex.Biophysical journal · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living cells are active viscoelastic materials exhibiting diverse mechanical behaviors at different time scales. However, dynamical rheological characteristics of cells in frequency range spanning many orders of magnitude, especially in high frequencies, remain poorly understood. Here, we show that a self-similar hierarchical model can capture cell's power-law rheological characteristics in different frequency scales. In low-frequency scales, the storage and loss moduli exhibit a weak power-law dependence on frequency with same exponent. In high-frequency scales, the storage modulus becomes a constant, while the loss modulus shows a power-law dependence on frequency with an exponent of 1.0. The transition between low- and high-frequency scales is defined by a transition frequency based on cell's mechanical parameters. The cytoskeletal differences of different cell types or states can be characterized by changes in mechanical parameters in the model. This study provides valuable insights into potentially using mechanics-based markers for cell classification and cancer diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.