Evidence map›Paper›PMID 35522722›Full record

ArticleScience immunology2022

Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.

Agata K Krzyzanowska, Rashade A H Haynes Ii, Damian Kovalovsky, Hsin-Ching Lin, Louis Osorio, Karen L Edelblum, Lynn M Corcoran, Arnold B Rabson, Lisa K Denzin, Derek B Sant'Angelo

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  6. Selective targeting or reprogramming of intra-tumoral Tregs.Medical oncology (Northwood, London, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Agata K KrzyzanowskaChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.ORCID 0000-0003-0005-7261
Rashade A H Haynes IiChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.ORCID 0000-0001-6690-1440
Damian KovalovskyCenter for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7040-8592
Hsin-Ching LinChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Louis OsorioChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Karen L EdelblumDepartment of Pathology and Laboratory Medicine Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0001-8288-4898
Lynn M CorcoranThe Walter and Eliza Hall Institute of Medical Research Immunology Division, Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia.
Arnold B RabsonChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Lisa K DenzinChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.ORCID 0000-0002-0554-4547
Derek B Sant'AngeloChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Rutgers, The State University of New Jersey · USNational Cancer Institute · USWalter and Eliza Hall Institute of Medical Research · AU

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Contribution of Innate-like Tregs for Preventing Tissue InflammationR01AI122757 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI SANT'ANGELO, DEREK B. · 2016 to 2021
$2.6M
Functional analysis of a novel Treg population identified by transcription factor profilingR21AI120600 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI SANT'ANGELO, DEREK B. · 2016 to 2017
$437k
NCI NIH HHS P30 CA072720NIAID NIH HHS R01 AI122757NIAID NIH HHS R21 AI120600
6 · The paper itself

Abstract

The expression of BTB-ZF transcription factors such as ThPOK in CD4

Indexed as

ColitisT-Lymphocytes, RegulatoryTranscription FactorsAnimalsHomeostasisIntestinesMiceMice, KnockoutTranscription FactorsZbtb20 protein, mouse

Identifiers

PMID35522722
PMCPMC9709958
OpenAlexW4229081699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.