ArticleProceedings of the National Academy of Sciences of the United States of America2022
Reduced H
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Bdelloid rotifers harbor a voltage-gated proton channel with distinct mechanistic features.Nature communications · 2026Article
- Biomass and coccolith productions in Chrysotila sp. in high density cultivation system.Applied microbiology and biotechnology · 2026Article
- Review
- Proton channels govern vesicular carbonate chemistry in mineralizing cells of a marine calcifier.Nature communications · 2026Article
- Substantial Limitations of Ocean Alkalinity Enhancement in Mitigating the Negative Impacts of Ocean Acidification on Marine Calcifiers.Environmental science & technology · 2026Article
- Article
- Helicosphaera carteri (Prymnesiophyceae) under high carbon dioxide: An experimental study.Journal of phycology · 2025Article
- Carbonate chemistry fitness landscapes inform diatom resilience to future perturbations.Science advances · 2025Article
- Solar-driven selective conversion of millimolar dissolved carbon to fuels with molecular flux generation.Nature communications · 2025Article
- Uncertain fate of pelagic calcifying protists: a cellular perspective on a changing ocean.The ISME journal · 2025Review
- Interaction with stomatin directs human proton channels into cholesterol-dependent membrane domains.Biophysical journal · 2024Article
- Transcendent Aspects of Proton Channels.Annual review of physiology · 2024Review
- Article
- Unexpected silicon localization in calcium carbonate exoskeleton of cultured and fossil coccolithophores.Scientific reports · 2023Article
- Voltage-gated proton channels explain coccolithophore sensitivity to ocean acidification.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coccolithophores are major producers of ocean biogenic calcite, but this process is predicted to be negatively affected by future ocean acidification scenarios. Since coccolithophores calcify intracellularly, the mechanisms through which changes in seawater carbonate chemistry affect calcification remain unclear. Here we show that voltage-gated H+ channels in the plasma membrane of Coccolithus braarudii serve to regulate pH and maintain calcification under normal conditions but have greatly reduced activity in cells acclimated to low pH. This disrupts intracellular pH homeostasis and impairs the ability of C. braarudii to remove H+ generated by the calcification process, leading to specific coccolith malformations. These coccolith malformations can be reproduced by pharmacological inhibition of H+ channels. Heavily calcified coccolithophore species such as C. braarudii, which make the major contribution to carbonate export to the deep ocean, have a large intracellular H+ load and are likely to be most vulnerable to future decreases in ocean pH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.