SynthesisPLoS neglected tropical diseases2022
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A reservoir at the gates: nonhuman mammalian hosts for human schistosomiasis in western Africa and the critical challenge for elimination.Infectious diseases of poverty · 2026Pooled it
- Prevalence and correlations of schistosomiasis mansoni and schistosomiasis haematobium among humans and intermediate snail hosts: a systematic review and meta-analysis.Infectious diseases of poverty · 2024Pooled it
- Article
- Improved serological testing for bovine schistosomiasis in Eastern Africa.Parasites & vectors · 2026Article
- Verifying interruption of transmission or elimination of Schistosoma japonicum must consider schistosome infections in wild rodents.PLoS neglected tropical diseases · 2025Article
- Cerebral Schistosomiasis in the Napu Valley, Central Sulawesi, Indonesia.Case reports in medicine · 2025Article
- One Health integrated surveillance: a way forward to accelerate schistosomiasis elimination in China.Science in One Health · 2025Review
- Seasonal distribution and cercarial shedding ofCurrent research in parasitology & vector-borne diseases · 2025Article
- Revealing bovine schistosomiasis in Malawi: Connecting human and hybrid schistosomes within cattle.One health (Amsterdam, Netherlands) · 2024Article
- A Recent Advance in the Diagnosis, Treatment, and Vaccine Development for Human Schistosomiasis.Tropical medicine and infectious disease · 2024Review
- Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice.Acta parasitologica · 2024Article
- Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis.PLoS neglected tropical diseases · 2023Article
- Population Genetics ofTropical medicine and infectious disease · 2023Article
- Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination.eLife · 2022Review
- The WHO new guideline to control and eliminate human schistosomiasis: implications for the verification of transmission interruption and surveillance of Schistosoma japonicum in China.Infectious diseases of poverty · 2022Article
- Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal.Parasites & vectors · 2022Article
- Elimination of schistosomiasis in China: Current status and future prospects.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundReliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. METHODOLOGY AND PRINCIPAL
findingsWe systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 19 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FEA-SD)) with quantitative polymerase chain reaction (qPCR), and sensitivity estimates (using qPCR as the reference) were extracted and included in the meta-analyses, showing significant heterogeneity across studies and animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). CONCLUSIONS/SIGNIFICANCE: Our findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts. Future studies are needed for validation and standardization of the techniques for real-world field applications.
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