ArticlePloS one2022
Molecular typing and prevalence of antibiotic resistance and virulence genes in Streptococcus agalactiae isolated from Chinese dairy cows with clinical mastitis.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Veterinary macrolides againstFrontiers in veterinary science · 2026Pooled it
- Prevalence and antimicrobial resistance ofOpen veterinary journal · 2025Pooled it
- Identification, antimicrobial resistance, and biofilm-forming capability of bacterial isolates from bovine mastitis in the high-altitude region of Shannan, Tibet.Archives of microbiology · 2026Article
- Detection ofVeterinary sciences · 2026Article
- Development and Application of a Dual-Readout RPA-PfAgo System for Rapid Detection ofVeterinary sciences · 2026Article
- Bovine Mastitis Therapy at a Crossroads: Pharmacokinetic Barriers, Biofilms, Antimicrobial Resistance, and Emerging Solutions.Pharmaceuticals (Basel, Switzerland) · 2026Review
- One Health Perspective on Antimicrobial Resistance in Bovine Mastitis Pathogens-A Narrative Review.Antibiotics (Basel, Switzerland) · 2026Review
- Chitosan nanoparticles as a sustainable antibacterial approach for inhibitingOpen veterinary journal · 2026Article
- Molecular Detection of Virulence Genes and Multi-drug Resistance Patterns inArchives of Razi Institute · 2025Article
- PlyCYU endolysin targetingApplied and environmental microbiology · 2025Article
- A Review on Bioengineering the Bovine Mammary Gland: The Role of the Extracellular Matrix and Reconstruction Prospects.Bioengineering (Basel, Switzerland) · 2025Review
- Genomic features and pathogenic potential ofJournal of advanced veterinary and animal research · 2025Article
- Capsular Typing and Molecular Characterization of Streptococcus agalactiae Strains Isolated From Bovine Mastitis in Iran.Veterinary medicine and science · 2025Article
- Virulence factors of bovine mastitis pathogens: distribution, pathogenesis, and emerging vaccines targeting virulence factors: a literature review.Frontiers in veterinary science · 2025Review
- Article
- The Contribution of Dairy Bedding and Silage to the Dissemination of Genes Coding for Antimicrobial Resistance: A Narrative Review.Antibiotics (Basel, Switzerland) · 2024Review
- Pharmacological composition based on bacteriocinnisin in experimentsOpen veterinary journal · 2024Article
- Identification of antibiotic resistance genes inVeterinarni medicina · 2024Article
- Characterization of Virulence Factors and Antimicrobial Susceptibility ofAnimals : an open access journal from MDPI · 2024Article
- Individual genomic loci, transcript level, and biochemical profile of immune and antioxidant markers associated with genetically identified bacterial mastitis in Shami goats in Egypt.Open veterinary journal · 2024Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine mastitis is a common disease occurring in dairy farms and can be caused by more than 150 species of pathogenic bacteria. One of the most common causative organisms is Streptococcus agalactiae, which is also potentially harmful to humans and aquatic animals. At present, research on S. agalactiae in China is mostly concentrated in the northern region, with limited research in the southeastern and southwestern regions. In this study, a total of 313 clinical mastitis samples from large-scale dairy farms in five regions of Sichuan were collected for isolation of S. agalactiae. The epidemiological distribution of S. agalactiae was inferred by serotyping isolates with multiplex polymerase chain reaction. Susceptibility testing and drug resistance genes were detected to guide the clinical use of antibiotics. Virulence genes were also detected to deduce the pathogenicity of S. agalactiae in Sichuan Province. One hundred and five strains of S. agalactiae (33.6%) were isolated according to phenotypic features, biochemical characteristics, and 16S rRNA sequencing. Serotype multiplex polymerase chain reaction analysis showed that all isolates were of type Ia. The isolates were up to 100% sensitive to aminoglycosides (kanamycin, gentamicin, neomycin, and tobramycin), and the resistance rate to β-lactams (penicillin, amoxicillin, ceftazidime, and piperacillin) was up to 98.1%. The TEM gene (β-lactam-resistant) was detected in all isolates, which was in accordance with a drug-resistant phenotype. Analysis of virulence genes showed that all isolates harbored the cfb, cylE, fbsA, fbsB, hylB, and α-enolase genes and none harbored bac or lmb. These data could aid in the prevention and control of mastitis and improve our understanding of epidemiological trends in dairy cows infected with S. agalactiae in Sichuan Province.
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