Evidence map›Paper›PMID 35522394›Full record

ArticleAdvances in therapy2022

The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome.

Brian Brocato, David Lewis, Fabien Eyal, Susan Baker, Casey Armistead, Alan David Kaye, Elyse M Cornett, Richard M Whitehurst

Abstract read

PubMed Publisher

In one paragraph

Article in Advances in therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

Interventions for opioid use disorder during pregnancy: a scoping review.Frontiers in psychiatry · 2026
Pooled it
A phase I pilot study of a mobile education tool for supporting pregnant women with opioid use disorder.Drug and alcohol dependence reports · 2025
Article
Breastfeeding Continuation at One Month Postpartum Among Women in Treatment for Opioid Use Disorder Who Initiated Breastfeeding: Prevalence and Determinants.Women's health reports (New Rochelle, N.Y.) · 2025
Article
Development of an Educational Brochure about Treatment Options for Pregnant Women with Opioid Use Disorders.Pharmacy (Basel, Switzerland) · 2024
Article
Breastfeeding Experiences in Women from Ten States Reporting Opioid Use Before or During Pregnancy: PRAMS, Phase 8.Maternal and child health journal · 2023
Article
Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids.Journal of personalized medicine · 2022
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian BrocatoDepartment of Obstetrics and Gynecology, University of Alabama, Birmingham, Birmingham, AL, USA.

David LewisDepartment of Obstetrics and Gynecology, Louisiana State University Health, Shreveport, Shreveport, LA, USA.

Fabien EyalDivision of Neonatology, University of South Alabama, Mobile, AL, USA.

Susan BakerDepartment of Obstetrics and Gynecology, University of South Alabama, Mobile, AL, USA.

Casey ArmisteadDepartment of Obstetrics and Gynecology, University of South Alabama, Mobile, AL, USA.

Alan David KayeDepartments of Anesthesiology and Pharmacology, Toxicology and Neurosciences, Louisiana State University Health Sciences Center, Shreveport, Shreveport, LA, USA.

Elyse M CornettDepartment of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. elyse.bradley@lsuhs.edu.

Richard M WhitehurstDivision of Neonatology, University of South Alabama, Mobile, AL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to determine the effect of a prenatal education program for opioid-dependent women on breastfeeding frequency, newborn hospital length of stay, and cost of care for neonates at risk of developing neonatal abstinence syndrome.

methodsFrom January 1, 2015 to January 1, 2020, opioid-dependent obstetric patients were educated on non-pharmacological preventative measures for neonatal abstinence syndrome (NAS), with focused counseling on breastfeeding. Data were collected and compared to a control group of opioid-dependent pregnant women who received standard care before initiation of the education program.

resultsSample size calculation revealed that to detect doubling of the breastfeeding rate from 25% to 50% with 80% power and α error of 0.05, 66 participants were required in each group.

conclusionThere were 75 women with opioid use disorder who had prenatal NAS education (study group) and 108 women with opioid use disorder who underwent standard care before NAS education (control group). Prenatal NAS education participants significantly increased breastfeeding initiation rates compared to the control group. Newborn length of stay significantly decreased after initiation of prenatal NAS education compared to the 36 months before NAS education program.

Indexed as

Neonatal Abstinence SyndromeOpioid-Related DisordersPrenatal EducationAnalgesics, OpioidBreast FeedingFemaleHumansInfantInfant, NewbornPregnancyAnalgesics, OpioidBreastfeedingNeonatal abstinence syndromeNewbornOpioid-dependentPrenatal

Identifiers

PMID35522394

DOI10.1542/peds.109.4.590

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.