Evidence map›Paper›PMID 35522383›Full record

ArticleInfection2022

Implementation of EACS vaccination recommendations among people living with HIV.

Sven Breitschwerdt, Carolynne Schwarze-Zander, Ahmad Al Tayy, Julia Mutevelli, Jan-Christian Wasmuth, Jürgen K Rockstroh, Christoph Boesecke

Abstract read
In one paragraph

Article in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sven BreitschwerdtDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany. Sven.Breitschwerdt@ukbonn.de.ORCID http://orcid.org/0000-0001-6585-1605
Carolynne Schwarze-ZanderDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
Ahmad Al TayyDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
Julia MutevelliDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
Jan-Christian WasmuthDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
Jürgen K RockstrohDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
Christoph BoeseckeDepartment of Internal Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWith modern combination antiretroviral Treatment (cART) a normal life expectancy among people living with HIV (PLWH) has become reality if started early enough prior to the onset of more pronounced immunodeficiency. Therefore, prevention measures against other infectious diseases among this vulnerable group have gained increased attention. Indeed, the EACS guidelines recommend vaccinations against HAV, HBV, HPV, Influenza, Neisseria meningitidis, Streptococcus pneumoniae and VZV in HIV-infected adults.

methodsAll PLWH under cART attending our ID outpatient clinic between April to June 2018, were assessed during consultation for vaccination status regarding pneumococcus, Hepatitis A and B, influenza, varicella, meningococcus and HPV using a pre-defined questionnaire, vaccination certificates and medical records. In addition, the cohort database was screened for Hepatitis A and B serology and HIV surrogate markers.

resultsA total of 305 PLWH (82.3% male, 17.7% female) was included, median age was 48 years (IQR 47-51). Median CD4 + T cell count was 543 (IQR 304-770), and for 297 (97.4%) PLWH CD4 + T cell count was ≥ 200/ul. The viral load was undetectable (< 40 copies/ml) in 289 (94.8%) cases. Highest vaccination rates were observed for HAV (87.4%), Streptococcus pneumoniae (77.4%) and Influenza (76.5%). 64.3% PLWH got vaccinated against HBV, whereas VZV vaccination only played a minor role, in the context of the high rate of cleared infections (99.0%). Lowest vaccination rates were detected for HPV (0%) and Neisseria meningitidis (3.0%).

conclusionsOur data suggest that vaccination rates among PLWH are higher compared to the general German population. Implementation of EACS guidelines into daily routine though is not fully executed and the need for improving vaccination rates has to be emphasized. Centrally organized vaccination registers as well as electronic medical records could be helpful tools to detect a lack of vaccination coverage and send digital vaccination reminders particularly among risk groups.

Indexed as

Hepatitis AHIV InfectionsInfluenza, HumanPapillomavirus InfectionsAdultCD4 Lymphocyte CountFemaleHumansMaleMiddle AgedSurveys and QuestionnairesVaccinationAIDSHIVPreventionVaccination

Identifiers

PMID35522383
PMCPMC9074432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.