ArticleEuropean journal of applied physiology2022
Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.
Article in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia.Scientific reports · 2026Article
- Peripheral vascular function, including endothelium-dependent measures, and dementia risk: The Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome.Clinical endocrinology · 2026Article
- Pulsatility index is a prognostic marker of cognitive outcome in patients with transient ischemic attack and mild acute stroke.Cerebral circulation - cognition and behavior · 2026Article
- Article
- Cerebrovascular adaptations to habitual resistance exercise with aging.American journal of physiology. Heart and circulatory physiology · 2024Review
- Cerebrovascular Reactivity Following Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2024Article
- Anthracycline chemotherapy, vascular dysfunction and cognitive impairment: burgeoning topics and future directions.Future cardiology · 2023Review
- The effect of levodopa treatment on vascular endothelial function in Parkinson's disease.Journal of neurology · 2023Article
- An examination of the relationship among plasma brain derived neurotropic factor, peripheral vascular function, and body composition with cognition in midlife African Americans/Black individuals.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOur aim was to compare cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and to determine which measures of vascular function best predict the presence of MCI.
methodsIn 41 adults with MCI and 33 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO
resultsCerebrovascular PI was higher in MCI compared with control (mean ± SD: 1.17 ± 0.27 vs. 1.04 ± 0.21), and MCI exhibited a lower %∆MCAv/%∆MAP (1.26 ± 0.44 vs. 1.50 ± 0.55%). Absolute (p = 0.76) and relative cerebrovascular reactivity to CO
conclusionThese findings raise the possibility that early changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular haemodynamics and impaired cognitive function, and present potential targets for prevention and treatment strategies in people with MCI.
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