Evidence map›Paper›PMID 35522226›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2022

Experimental study on novel biodegradable Zn-Fe-Si alloys.

Yuxin Zeng, Zeyi Guan, Chase S Linsley, Shuaihang Pan, Jingke Liu, Benjamin M Wu, Xiaochun Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuxin ZengDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
Zeyi GuanDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
Chase S LinsleyDepartment of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.ORCID 0000-0002-8259-5487
Shuaihang PanDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
Jingke LiuDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
Benjamin M WuDepartment of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
Xiaochun LiDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Novel Zinc-Nanocomposite Materials for Pediatric Bioresorbable Cardiovascular StentsR01HL143465 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVI, DANIEL STEVEN, LI, XIAOCHUN · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL143465
6 · The paper itself

Abstract

Bioabsorbable metals are increasingly attracting attention for their potential use as materials for degradable implant devices. Zinc (Zn) alloys have shown great promises due to their good biocompatibility and favorable degradation rate. However, it has been difficult to maintain an appropriate balance among strength, ductility, biocompatibility, and corrosion rate for Zn alloys historically. In this study, the microstructure, chemical composition, mechanical properties, biocompatibility, and corrosion rate of a new ternary zinc-iron-silicon (Zn-Fe-Si) alloy system was studied as a novel material for potential biodegradable implant applications. The results demonstrated that the in situ formed Fe-Si intermetallic phases enhanced the mechanical strength of the material while maintaining a favorable ductility. With Fe-Si reinforcements, the microhardness of the Zn alloys was enhanced by up to 43%. The tensile strength was increased by up to 76% while elongation to failure remained above 30%. Indirect cytotoxicity testing showed the Zn-Fe-Si system had good biocompatibility. Immersion testing revealed the corrosion rate of Zn-Fe-Si system was not statistically different from pure Zn. To understand the underlying phase formation mechanism, the reaction process in this ternary system during the processing was also studied via phase evolution and Gibbs free energy analysis. The results suggest the Zn-Fe-Si ternary system is a promising new material for bioabsorbable metallic medical devices.

Indexed as

AlloysZincAbsorbable ImplantsBiocompatible MaterialsCorrosionMaterials TestingAlloysBiocompatible MaterialsZincbiocompatibilitybiodegradablein situ formed intermetallicmechanical propertiesZn-Fe-Si alloys

Identifiers

PMID35522226
PMCPMC9378461
OpenAlexW4229034402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.