ReviewThe Journal of experimental medicine2022
Neutrophil phenotypes and functions in cancer: A consensus statement.
Open access · hybridAbstract readReviewConsensus Statement
In one paragraph
Review in The Journal of experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 2 pooled it
27.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
201 citing papers in PubMed, 2 syntheses or guidelines pooled it, 333 citations in OpenAlex.
- The predictive value of the neutrophil/eosinophil ratio in cancer patients undergoing immune checkpoint inhibition: a meta-analysis and a validation cohort in hepatocellular carcinoma.Frontiers in immunology · 2025Pooled it
- Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli.Frontiers in immunology · 2023Pooled it
- Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.Oncoimmunology · 2026Article
- Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis.Cancer discovery · 2026Article
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- Clinical Value of an LDH-CA125-NLR Panel for Diagnosis, Platinum Resistance, and Prognostic Assessment in Epithelial Ovarian Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Neutrophils in cancer.Nature reviews. Cancer · 2026Review
- Role of DLL4 in Neutrophil Aging and Impaired Clearance in Sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis Through Symbiotic Adhesion and Reverse Migration.Cancer research · 2026Article
- Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour.Nature metabolism · 2026Article
- Injectable Thermosensitive Hydrogel Targeting STAT3 Reprograms Neutrophils to Amplify Anti-Tumor Immunity Post-Radiofrequency Ablation in HCC.Advanced healthcare materials · 2026Article
- Human immunosuppressive neutrophils: recent answers to old and new questions.The EMBO journal · 2026Review
- Retargeted adenoviruses for local IgA and CD47 blocker production as a novel cancer therapy.EMBO molecular medicine · 2026Article
- Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis.Science advances · 2026Article
- Safety assessment of Neulasta® (pegfilgrastim) in patients with solid tumors: a real-world adverse event analysis from the FAERS database.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Neutrophil extracellular traps (NETosis) in gynecologic cancers: from pathogenesis to therapeutic opportunities: a narrative review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- New Insights Into the Role of Neutrophils in Lymphoma.Cancer medicine · 2026Review
- Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer.Nature communications · 2026Article
141 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 20 institutions in 9 countries.
Daniela F QuailRosalind and Morris Goodman Cancer Institute, Department of Physiology, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-6969-3250
Borko AmulicCellular and Molecular Medicine, University of Bristol, Bristol, UK.ORCID 0000-0002-8518-8393
Monowar AzizCenter for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY.ORCID 0000-0002-8195-4505
Betsy J BarnesCenter for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, NY.ORCID 0000-0001-6766-4352
Evgeniy EruslanovDivision of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-0743-5026
Zvi G FridlenderHadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0002-6122-1988
Helen S GoodridgeBoard of Governors Regenerative Medicine Institute and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-8097-2413
Zvi GranotDepartment of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0001-9692-5785
Andrés HidalgoVascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-5513-555X
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0001-7940-6254
Mariana J KaplanSystemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2968-0815
Ilaria MalanchiTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0003-4867-3311
Taha MerghoubLudwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1518-5111
Etienne MeylanLung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Université Libre de Bruxelles, Anderlecht, Belgium.ORCID 0000-0002-0899-2230
Vivek MittalDepartment of Cardiothoracic Surgery, Neuberger Berman Foundation Lung Cancer Research Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-4764-7413
Mikael J PittetDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-2060-4691
Andrea Rubio-PonceArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID 0000-0002-4275-8835
Irina A UdalovaUniversity of Oxford, Kennedy Institute of Rheumatology, Oxford, UK.ORCID 0000-0002-6716-2528
Timo K van den BergLaboratory of Immunotherapy, Sanquin Research, Amsterdam, Netherlands.ORCID 0000-0002-2052-3904
Denisa D WagnerProgram in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-4494-413X
Ping WangCenter for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY.ORCID 0000-0002-1557-0394
Arturo ZychlinskyDepartment of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.ORCID 0000-0001-6018-193X
Karin E de VisserDivision of Tumour Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID 0000-0002-0293-868X
Mikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY.ORCID 0000-0002-3371-1445
Paul KubesDepartment of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-2835-4244
Feinstein Institute for Medical Research · USCold Spring Harbor Laboratory · USHebrew University of Jerusalem · ILSpanish National Centre for Cardiovascular Research · ESBoston Children's Hospital · USCedars-Sinai Medical Center · USCornell University · USMax Planck Institute for Infection Biology · DEMcGill University · CAMemorial Sloan Kettering Cancer Center · USNational Institutes of Health · USSanquin · NLThe Francis Crick Institute · GBUniversité Libre de Bruxelles · BEUniversity of Bristol · GBUniversity of Calgary · CAUniversity of Geneva · CHUniversity of Oxford · GBUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MSystemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5MStrategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI PAI, SARA ISABEL · 2019 to 2023
$8.4MADHESIVE REGULATION DURING CELL MIGRATIONR01CA085862 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2000 to 2026
$7.3MHow inflammation and thrombosis fuel disease and aging: Focus on NETsR35HL135765 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WAGNER, DENISA D · 2017 to 2023
$6.2MIMMUNIZATION AGAINST MELANOMA DIFFERENTIATION ANTIGENSR01CA056821 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI WOLCHOK, JEDD D. · 1992 to 2020
$5.7MNovel Approaches to Maintaining Organ Function in SepsisR35GM118337 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PING WANG · 2016 to 2026
$5.2MIRF5 and Macrophage Activation Syndrome in systemic Juvenile Idiopathic ArthritisR01AR076242 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BARNES, BETSY J, HAMERMAN, JESSICA A · 2019 to 2023
$3.3MSingle Cell Genome-Wide Myeloid Response Profiling in ImmunotherapyR01CA218579 · NCI · HARVARD MEDICAL SCHOOL · PI KLEIN, ALLON MOSHE, PITTET, MIKAEL · 2018 to 2022
$2.7MMonocyte Production by Bone Marrow ProgenitorsR01AI134987 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI GOODRIDGE, HELEN S · 2018 to 2022
$2.5MTumor-associated neutrophils in human lung cancerR01CA187392 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERUSLANOV, EVGENIY · 2016 to 2020
$1.8MNeutrophils in Sepsis: Role of CIRPR01GM129633 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI AZIZ, MONOWAR · 2018 to 2022
$1.6MEuropean Research Council ERC CoG-H2020-725492Intramural NIH HHS ZIA AR041199Medical Research Council MR/R02149x/1NCI NIH HHS P01 CA240239NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA056821NCI NIH HHS R01 CA085862NCI NIH HHS R01 CA187392NCI NIH HHS R01 CA218579NHLBI NIH HHS R35 HL135765NIAID NIH HHS R01 AI134987NIAMS NIH HHS AR065959-01NIAMS NIH HHS R01 AR076242NIAMS NIH HHS R21 AR065959NIGMS NIH HHS R01 GM129633NIGMS NIH HHS R35 GM118337NIGMS NIH HHS R35GM118337Swiss National Science Foundation 310030_179324Wellcome Trust 209422/Z/17/ZWellcome Trust FC001112
Abstract
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
Indexed as
NeoplasmsNeutrophilsHumansImmunity, InnateInflammationPhenotype
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.