Evidence map›Paper›PMID 35522139›Full record

Trial reportRadiology. Imaging cancer2022

Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases.

Nina J Wesdorp, Ruby Kemna, Karen Bolhuis, Jan H T M van Waesberghe, Irene M G C Nota, Femke Struik, Ikrame Oulad Abdennabi, Saffire S K S Phoa, Susan van Dieren, Martinus J van Amerongen and 23 more

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology. Imaging cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02162563 (Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases CAIRO5 a Randomized Phase 3 Study of the Dutch Colorectal Cancer Group), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02162563 phase3completednot on this map

Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases CAIRO5 a Randomized Phase 3 Study of the Dutch Colorectal Cancer Group (DCCG)

TypeinterventionalSponsorDutch Colorectal Cancer GroupRan2014 to 2025Enrolled530ConditionsColorectal Cancer, Liver MetastasesArmsFOLFOX/ FOLFIRI with bevacizumab, FOLFOXIRI with bevacizumab, FOLFOX/ FOLFIRI with panitumumab
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 2 institutions in 3 countries.

Nina J Wesdorp *From the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).ORCID 0000-0003-4234-5915
Ruby Kemna *From the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Karen BolhuisFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Jan H T M van WaesbergheFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Irene M G C NotaFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Femke StruikFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Ikrame Oulad AbdennabiFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Saffire S K S PhoaFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Susan van DierenFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Martinus J van AmerongenFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Thiery ChapelleFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Cornelis H C DejongFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Marc R W EngelbrechtFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Michael F GerhardsFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Dirk GrünhagenFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).ORCID 0000-0001-8293-6002
Thomas M van GulikFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
John J HermansFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Koert P de JongFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).ORCID 0000-0001-6345-653X
Joost M KlaaseFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Mike S L LiemFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Krijn P van LiendenFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
I Quintus MolenaarFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Gijs A PatijnFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Arjen M RijkenFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Theo M RuersFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Cornelis VerhoefFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Johannes H W de WiltFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Rutger-Jan SwijnenburgFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Cornelis J A PuntFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Joost HuiskensFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Jaap Stoker *From the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).ORCID 0000-0002-9822-3784
Geert Kazemier *From the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Dutch Colorectal Liver Expert PanelFrom the Department of Surgery (N.J.W., R.K., G.K.) and Department of Radiology and Nuclear Medicine (J.H.T.M.v.W., I.M.G.C.N., F.S., I.O.A., S.S.K.S.P., M.R.W.E., J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Medical Oncology (K.B., C.J.A.P.) and Department of Surgery (S.v.D., T.M.v.G., R.J.S.), Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Imaging, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (M.J.v.A., J.J.H.); Department of Hepatobiliary, Transplantation, and Endocrine Surgery, Antwerp University Hospital, Antwerp, Belgium (T.C.); Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (C.H.C.D.); Department of Surgery, Universitätsklinikum Aachen, Aachen, Germany (C.H.C.D.); Department of Surgery, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands (M.F.G.); Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (D.G., C.V.); Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands (K.P.d.J., J.M.K.); Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands (M.S.L.L.); Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (K.P.v.L.); Department of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St Antonius Hospital, Nieuwegein, the Netherlands (I.Q.M.); Department of Surgery, Isala Hospital, Zwolle, the Netherlands (G.A.P.); Department of Surgery, Amphia Hospital, Breda, the Netherlands (A.M.R.); Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands (T.M.R.); Department of Surgery, Radboud University Medical Center, Radboud University Nijmegen, Nijmegen, the Netherlands (J.H.W.d.W.); Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands (C.J.A.P.); and Department of Health, SAS Institute, Huizen, the Netherlands (J.H.).
Radboud University Nijmegen · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To evaluate interobserver variability in the morphologic tumor response assessment of colorectal liver metastases (CRLM) managed with systemic therapy and to assess the relation of morphologic response with gene mutation status, targeted therapy, and Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 measurements. Materials and Methods Participants with initially unresectable CRLM receiving different systemic therapy regimens from the randomized, controlled CAIRO5 trial (NCT02162563) were included in this prospective imaging study. Three radiologists independently assessed morphologic tumor response on baseline and first follow-up CT scans according to previously published criteria. Two additional radiologists evaluated disagreement cases. Interobserver agreement was calculated by using Fleiss κ. On the basis of the majority of individual radiologic assessments, the final morphologic tumor response was determined. Finally, the relation of morphologic tumor response and clinical prognostic parameters was assessed. Results In total, 153 participants (median age, 63 years [IQR, 56-71]; 101 men) with 306 CT scans comprising 2192 CRLM were included. Morphologic assessment performed by the three radiologists yielded 86 (56%) agreement cases and 67 (44%) disagreement cases (including four major disagreement cases). Overall interobserver agreement between the panel radiologists on morphology groups and morphologic response categories was moderate (κ = 0.53, 95% CI: 0.48, 0.58 and κ = 0.54, 95% CI: 0.47, 0.60). Optimal morphologic response was particularly observed in patients treated with bevacizumab (

Indexed as

Colorectal NeoplasmsLiver NeoplasmsFemaleHumansMaleMiddle AgedObserver VariationProspective StudiesTomography, X-Ray ComputedAbdomen/GastrointestinalCTLiverMetastasesObserver PerformanceOncologyTumor Response

Identifiers

PMID35522139
PMCPMC9152692
OpenAlexW4228996516

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