ArticleeLife2022
Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents.American journal of physiology. Renal physiology · 2026Article
- Real-time wavelet threshold denoising for laser speckle blood flow imaging.Scientific reports · 2026Article
- The nephron arterial network and its interactions: nonlinear and information theoretic analyses.Frontiers in network physiology · 2026Article
- Life in the fast lane: Functional consequences of male-female dynamic differences in the renal auto-regulation of flow.bioRxiv : the preprint server for biology · 2025Article
- Three dimensional multiscalar neurovascular nephron connectivity map of the human kidney across the lifespan.Nature communications · 2025Article
- Laser speckle contrast imaging of hepatic microcirculation.Biomedical optics express · 2025Article
- Response of the Nephron Arterial Network and Its Interactions to Acute Hypertension: A Simulation.Function (Oxford, England) · 2025Article
- Hematological, biochemical, and antioxidant status in sheep with skin disorders suffering from zinc, copper, and vitamin A deficiencies.Open veterinary journal · 2025Article
- Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats.American journal of physiology. Renal physiology · 2024Article
- Choosing a polarisation configuration for dynamic light scattering and laser speckle contrast imaging.Biomedical optics express · 2024Article
- In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys.Scientific reports · 2023Article
- The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging.Physiological reports · 2023Article
- Reduced tubuloglomerular feedback activity and absence of its synchronization in a connexin40 knockout rat.Frontiers in network physiology · 2023Article
- Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging.American journal of physiology. Renal physiology · 2022Article
- Relationship of Effective Circulating Volume with Sublingual Red Blood Cell Velocity and Microvessel Pressure Difference: A Clinical Investigation and Computational Fluid Dynamics Modeling.Journal of clinical medicine · 2022Article
- Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging.eLife · 2022Article
- Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internephron interaction is fundamental for kidney function. Earlier studies have shown that nephrons signal to each other, synchronize over short distances, and potentially form large synchronized clusters. Such clusters would play an important role in renal autoregulation, but due to the technological limitations, their presence is yet to be confirmed. In the present study, we introduce an approach for high-resolution laser speckle imaging of renal blood flow and apply it to estimate the frequency and phase differences in rat kidney microcirculation under different conditions. The analysis unveiled the spatial and temporal evolution of synchronized blood flow clusters of various sizes, including the formation of large (>90 vessels) and long-lived clusters (>10 periods) locked at the frequency of the tubular glomerular feedback mechanism. Administration of vasoactive agents caused significant changes in the synchronization patterns and, thus, in nephrons' co-operative dynamics. Specifically, infusion of vasoconstrictor angiotensin II promoted stronger synchronization, while acetylcholine caused complete desynchronization. The results confirm the presence of the local synchronization in the renal microcirculatory blood flow and that it changes depending on the condition of the vascular network and the blood pressure, which will have further implications for the role of such synchronization in pathologies development.
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