Evidence map›Paper›PMID 35522033›Full record

ArticleDiabetes care2022

Carbohydrate Tolerance Threshold for Unannounced Snacks in Children and Adolescents With Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System.

Gianluca Tornese, Claudia Carletti, Manuela Giangreco, Daniela Nisticò, Elena Faleschini, Egidio Barbi

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06130215 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluation on Glycemic Control Using Two Different Meal Announcement Plans in Adolescents With Type 1 Diabetes on Minimed 780G Hybrid Closed Loop System

TypeinterventionalSponsorSidra MedicineRan2023 to 2025Enrolled34ConditionsType 1 DiabetesArmsSimple meal management, Precise meal management
NCT07031492 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Beyond Hybrid Artificial Pancreas Systems: Relieving Carb Counting Via Flexible-userinteraction Multiple-input Control Architectures

TypeinterventionalSponsorFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalRan2025 to 2025Enrolled10ConditionsT1DM - Type 1 Diabetes MellitusArmsFLEX-AP system will be implemented to T1D patients
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gianluca TorneseInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.ORCID 0000-0002-4395-3915
Claudia CarlettiInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
Manuela GiangrecoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
Daniela NisticòDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Elena FaleschiniInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
Egidio BarbiInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
IRCCS Materno Infantile Burlo Garofolo · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo find a carbohydrate (CHO) tolerance threshold for unannounced snacks to avoid the 2 h increase in glycemia (difference between pre- and postmeal blood glucose [ΔBG]) ≥50 mg/dL in advanced hybrid closed-loop (a-HCL) users. RESEARCH DESIGN AND

methodsFourteen children and adolescents with type 1 diabetes (7 females; mean age [± SD] 14.5 ± 3.6 years), users of the Medtronic MiniMed 780G, participated in the study. For 12 days, they did not perform insulin bolus before breakfasts, with defined different quantities and types of CHO, with or without fats, performing blood glucose (BG) before and 2 h after the meal.

resultsA cutoff of 19.8 g of total CHO was found to determine a ΔBG of 50 mg/dL. BG never exceeded 250 mg/dL. Mean time in range was ≥70% in the 2 h following each snack.

conclusionsUnannounced snacks of up to 20 g of CHO can avoid ΔBG ≥50 mg/dL in MiniMed 780G users, although unannounced meals of up to 30 g of CHO are safe.

Indexed as

Diabetes Mellitus, Type 1AdolescentBlood GlucoseBlood Glucose Self-MonitoringChildFemaleHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsSnacksBlood GlucoseHypoglycemic AgentsInsulin

Identifiers

PMID35522033
PMCPMC9210515
OpenAlexW4229022927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.