ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Why a Diffusing Single-Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Plasmonic Film with Diluted Nanostructures for Light Energy Harvesting and Sensing.ACS applied optical materials · 2025Article
- Graphene-Based Opto-Electronic Platform for Ultra-Sensitive Biomarker Detection at Zeptomolar Concentrations.Small methods · 2025Article
- Plasmonic Single-Molecule Affinity Detection at 10Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Piercing the Shadows: Exploring the Influence of Signal Preprocessing on Interpreting Ultrasensitive Bioelectronic Sensor Data.ChemPlusChem · 2025Article
- Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit.Cell reports. Physical science · 2024Article
- Sensors for in situ monitoring of oral and dental health parameters in saliva.Clinical oral investigations · 2023Review
- Immuno-Sensing at Ultra-Low Concentration of TG2 Protein by Organic Electrochemical Transistors.Biosensors · 2023Article
- Organic Bioelectronics Development in Italy: A Review.Micromachines · 2023Review
- Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Why a Diffusing Single-Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Single-molecule detection at a nanometric interface in a femtomolar solution, can take weeks as the encounter rate between the diffusing molecule to be detected and the transducing nanodevice is negligibly small. On the other hand, several experiments prove that macroscopic label-free sensors based on field-effect-transistors, engaging micrometric or millimetric detecting interfaces are capable to assay a single-molecule in a large volume within few minutes. The present work demonstrates why at least a single molecule out of a few diffusing in a 100 µL volume has a high probability to hit a large capturing and detecting electronic interface. To this end, sensing data, measured with an electrolyte-gated FET whose gate is functionalized with 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.