Evidence map›Paper›PMID 35521812›Full record

ReviewAnnals of medicine2022

The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS.

Y Tong, E Orang'o, M Nakalembe, P Tonui, P Itsura, K Muthoka, M Titus, S Kiptoo, A Mwangi, J Ong'echa and 21 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 10 institutions in 3 countries.

Y TongIndiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-2784-3118
E Orang'oMoi University, Eldoret, Kenya.
M NakalembeInfectious Diseases Institute, Makerere University, Kampala, Uganda.
P TonuiMoi University, Eldoret, Kenya.
P ItsuraMoi University, Eldoret, Kenya.
K MuthokaMoi University, Eldoret, Kenya.
M TitusMaseno University, Kisumu, Kenya.
S KiptooMoi University, Eldoret, Kenya.
A MwangiMoi University, Eldoret, Kenya.
J Ong'echaKenya Medical Research Institute, Eldoret, Kenya.
R TonuiMoi University, Eldoret, Kenya.
B OdongoMoi University, Eldoret, Kenya.
C MpamaniInfectious Diseases Institute, Makerere University, Kampala, Uganda.
B RosenBeaumont Gynecology Oncology, Royal Oak, MI, USA.
A MoormannUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
S Cu-UvinBrown University, Providence, RI, USA.
J A BaileyBrown University, Providence, RI, USA.
C I OduorBrown University, Providence, RI, USA.
A ErmelIndiana University School of Medicine, Indianapolis, IN, USA.
C YiannoutsosIndiana University School of Medicine, Indianapolis, IN, USA.
B MusickIndiana University School of Medicine, Indianapolis, IN, USA.
E SangAMPATH, Eldoret, Kenya.
A NgeresaAMPATH, Eldoret, Kenya.
G BanturakiInfectious Diseases Institute, Makerere University, Kampala, Uganda.
A KiraggaInfectious Diseases Institute, Makerere University, Kampala, Uganda.
J ZhangIndiana University Fairbanks School of Public Health, Indianapolis, IN, USA.
Y SongIndiana University Fairbanks School of Public Health, Indianapolis, IN, USA.
S ChintalaIndiana University School of Medicine, Indianapolis, IN, USA.
R KatzenellenbogenIndiana University School of Medicine, Indianapolis, IN, USA.
P LoehrerIndiana University School of Medicine, Indianapolis, IN, USA.
D R BrownIndiana University School of Medicine, Indianapolis, IN, USA.
Moi University · KEUniversity School · USInfectious Diseases Institute · UGJohn Brown University · USAMPATH · KEIndiana University – Purdue University Indianapolis · USBeaumont Health · USKenya Medical Research Institute · KEMaseno University · KEUniversity of Massachusetts Chan Medical School · US

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
Translational CoreU54CA254518 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KATZENELLENBOGEN, RACHEL ADRIA · 2020 to 2024
$4.7M
NCI NIH HHS U54 CA254518NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

The East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer, and to encourage collaborations between researchers in North America and East African countries. To date, studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on the persistence of HPV, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP. It will now be determined how HPV testing fits into cervical cancer screening programs in Kenya and Uganda, how aflatoxin influences immunological control of HIV, how HPV alters certain genes involved in the growth of tumours in HIV-infected women. Although there have been challenges in performing this research, with time, this work should help to reduce the burden of cervical cancer and other cancers related to HIV infection in people living in sub-Saharan Africa, as well as optimized processes to better facilitate research as well as patient autonomy and safety. KEY MESSAGESThe East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer.Collaborations have been established between researchers in North America and East African countries for these studies.Studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on HPV detection, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP.

Indexed as

AflatoxinsAlphapapillomavirusHIV InfectionsPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsEarly Detection of CancerFemaleHumansPapillomaviridaeAflatoxinscervical cancerHIVHPVKenyaUganda

Identifiers

PMID35521812
PMCPMC9090376
OpenAlexW4229037949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.