Evidence map›Paper›PMID 35521565›Full record

ArticleRSC advances2018

Photo-curable poly-(ethylene glycol)-fumarate elastomers with controlled structural composition and their evaluation as eluting systems.

Lucila Navarro, Roque J Minari, Santiago E Vaillard

Abstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lucila NavarroInstituto de Desarrollo Tecnológico para la Industria Química (INTEC), CCT-Santa Fe CONICET-UNL. Colectora Ruta Nacional 168, Km 1, Predio "Dr. Alberto Cassano", Paraje "EL Pozo" Santa Fe 3000 Argentina svaillard@intec.unl.edu.ar.ORCID https://orcid.org/0000-0002-6131-3655
Roque J MinariInstituto de Desarrollo Tecnológico para la Industria Química (INTEC), CCT-Santa Fe CONICET-UNL. Colectora Ruta Nacional 168, Km 1, Predio "Dr. Alberto Cassano", Paraje "EL Pozo" Santa Fe 3000 Argentina svaillard@intec.unl.edu.ar.ORCID https://orcid.org/0000-0003-3645-5317
Santiago E VaillardInstituto de Desarrollo Tecnológico para la Industria Química (INTEC), CCT-Santa Fe CONICET-UNL. Colectora Ruta Nacional 168, Km 1, Predio "Dr. Alberto Cassano", Paraje "EL Pozo" Santa Fe 3000 Argentina svaillard@intec.unl.edu.ar.ORCID https://orcid.org/0000-0002-7863-3348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work we prepared a new family of photo-curable poly-(ethylene glycol)-fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate pre-polymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems. Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.

Identifiers

PMID35521565
PMCPMC9059383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.