ArticleiScience2022
A network model of glymphatic flow under different experimentally-motivated parametric scenarios.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- High frame ratebioRxiv : the preprint server for biology · 2026Article
- Enhanced Taylor-Aris dispersion in slender pulsatile annular channels: Implications for perivascular solute transport.Journal of fluid mechanics · 2026Article
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Fluids and barriers of the CNS · 2026Article
- Mapping the Brain's Glymphatic System.Biomedicines · 2026Review
- Dynamics of brain valves: ostensible rectification mechanisms for cerebrospinal fluid flow.Journal of the Royal Society, Interface · 2025Article
- Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain.Fluids and barriers of the CNS · 2025Article
- Should poor sleep be added to the list of risk factors for normal-tension glaucoma in the future?Eye (London, England) · 2025Article
- Advection and diffusion in perivascular and extracellular spaces in the brain.Journal of the Royal Society, Interface · 2025Article
- Arterial pulsations and transmantle pressure synergetically drive glymphatic flow.Scientific reports · 2025Article
- Could Sleep Be an Antidote to Optic Disc Edema in Astronauts?Life (Basel, Switzerland) · 2025Article
- Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull.Fluids and barriers of the CNS · 2024Article
- Blood osmolytes such as sugar can drive brain fluid flows in a poroelastic model.Scientific reports · 2024Article
- Directional flow in perivascular networks: mixed finite elements for reduced-dimensional models on graphs.Journal of mathematical biology · 2024Article
- Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries.Fluids and barriers of the CNS · 2024Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Mouse brain elastography changes with sleep/wake cycles, aging, and Alzheimer's disease.NeuroImage · 2024Article
- Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies.Cellular and molecular life sciences : CMLS · 2024Review
- Modeling of brain efflux: Constraints of brain surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gaps in the wall of a perivascular space act as valves to produce a directed flow of cerebrospinal fluid: a hoop-stress model.Journal of the Royal Society, Interface · 2024Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Fluids and barriers of the CNS · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain delivers nutrients, clears metabolic waste, and causes edema formation. Brain-wide imaging cannot resolve PVSs, and high-resolution methods cannot access deep tissue. However, theoretical models provide valuable insight. We model the CSF pathway as a network of hydraulic resistances, using published parameter values. A few parameters (permeability of PVSs and the parenchyma, and dimensions of PVSs and astrocyte endfoot gaps) have wide uncertainties, so we focus on the limits of their ranges by analyzing different parametric scenarios. We identify low-resistance PVSs and high-resistance parenchyma as the only scenario that satisfies three essential criteria: that the flow be driven by a small pressure drop, exhibit good CSF perfusion throughout the cortex, and exhibit a substantial increase in flow during sleep. Our results point to the most important parameters, such as astrocyte endfoot gap dimensions, to be measured in future experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.