Evidence map›Paper›PMID 35521469›Full record

ArticleRSC advances2020

Stable antibacterial polysaccharide-based hydrogels as tissue adhesives for wound healing.

Xiaoxuan Tang, Xinyi Gu, Yaling Wang, Xiaoli Chen, Jue Ling, Yumin Yang

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 60 citations in OpenAlex.

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  15. Frontiers in physiology · 2021
    Article
  16. Article
  17. Article
  18. Polymer nanomaterials for use as adjuvant surgical tools.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 3 countries.

Xiaoxuan TangKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Nantong University Nantong 226001 PR China yangym@ntu.edu.cn jl2016@ntu.edu.cn.
Xinyi GuKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Nantong University Nantong 226001 PR China yangym@ntu.edu.cn jl2016@ntu.edu.cn.
Yaling WangSchool of Pharmacy, Nantong University Nantong 226001 PR China.
Xiaoli ChenKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Nantong University Nantong 226001 PR China yangym@ntu.edu.cn jl2016@ntu.edu.cn.
Jue LingKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Nantong University Nantong 226001 PR China yangym@ntu.edu.cn jl2016@ntu.edu.cn.ORCID https://orcid.org/0000-0003-0159-6611
Yumin YangKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Nantong University Nantong 226001 PR China yangym@ntu.edu.cn jl2016@ntu.edu.cn.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adhesion to the surface of moist, dynamic, biological tissues is important in many fields. Currently, tissue adhesives commonly used in clinical practice remain far from ideal, exhibiting either poor tissue compatibility or weak tissue adhesion. Here, we designed biocompatible hydrogels comprising polysaccharides with polyacrylamide and exhibiting promising cytocompatibility, antibacterial activity, and excellent tissue adhesion. Alginate/chitosan-based hydrogels covalently cross-linked to the tissue surface in order to achieve admirable tissue adhesion. Additionally, the mechanical properties of the hydrogels were significantly enhanced with the addition of polyacrylamide, which synergistically promoted their enhanced adhesion. Importantly, the hydrogels exhibited good biocompatibility and reasonable antibacterial activity that promoted wound recovery during use as wound dressings. These results suggested the efficacy of the developed tissue adhesives for applications in biomedical fields, as well as broadening potential hydrogel use in tissue engineering.

Identifiers

PMID35521469
PMCPMC9053413
OpenAlexW3022929117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.