Evidence map›Paper›PMID 35521273›Full record

ArticleRSC advances2020

Natural deep eutectic solvent supported targeted solid-liquid polymer carrier for breast cancer therapy.

Xianfu Sun, Periyakaruppan Pradeepkumar, Naresh Kumar Rajendran, Harshavardhan Shakila, Nicolette Nadene Houreld, Dunia A Al Farraj, Yousif M Elnahas, Nandhakumar Elumalai, Mariappan Rajan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 6 countries.

Xianfu SunDepartment of Breast, The Affiliated Tumor Hospital of Zhengzhou University Zhengzhou Henan 450008 China.
Periyakaruppan PradeepkumarBiomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University Madurai-625021 Tamil Nadu India rajanm153@gmail.com.
Naresh Kumar RajendranLaser Research Centre, Faculty of Health Sciences, University of Johannesburg PO Box 17011 Doornfontein 2028 South Africa.
Harshavardhan ShakilaDepartment of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University Madurai-625021 India.
Nicolette Nadene HoureldLaser Research Centre, Faculty of Health Sciences, University of Johannesburg PO Box 17011 Doornfontein 2028 South Africa.
Dunia A Al FarrajDepartment of Botany and Microbiology, College of Science, King Saud University Riyadh 11451 Saudi Arabia.
Yousif M ElnahasDepartment of Surgery, College of Medicine, King Saud University Medical City, King Saud University Riyadh Saudi Arabia.
Nandhakumar ElumalaiDepartment of Biochemistry, Sri Muthukumaran Medical College and Research Institute Chennai-600069 Tamil Nadu India.
Mariappan RajanBiomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University Madurai-625021 Tamil Nadu India rajanm153@gmail.com.ORCID https://orcid.org/0000-0001-9569-8744
Madurai Kamaraj University · INUniversity of Johannesburg · ZAKing Saud Medical City · SAKing Saud University · SATamil Nadu Dr. M.G.R. Medical University · INZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid-liquid nanocarriers (SLNs) are at the front of the rapidly emerging field of medicinal applications with a potential role in the delivery of bioactive agents. Here, we report a new SLN of natural deep eutectic solvent (NADES) and biotin-conjugated lysine-polyethylene glycol copolymer. The SLN system was analyzed for its functional groups, thermal stability, crystalline nature, particle size, and surface morphology through the instrumental analysis of FT-IR, TGA, XRD, DLS, SEM, and TEM. Encapsulation of PTX (paclitaxel) and 7-HC (7-hydroxycoumarin) with the SLN was carried out by dialysis, and UV-visible spectra evidenced the drug loading capacity and higher encapsulation efficiency obtained. The enhanced anticancer potential of PTX- and 7-HC-loaded SLN was assessed

Identifiers

PMID35521273
PMCPMC9057073
OpenAlexW3091845225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.