Evidence map›Paper›PMID 35521223›Full record

ArticleFrontiers in cellular and infection microbiology2022

Nrf2 Activation Protects Against Organic Dust and Hydrogen Sulfide Exposure Induced Epithelial Barrier Loss and

Denusha Shrestha, Nyzil Massey, Sanjana Mahadev Bhat, Tomislav Jelesijević, Orhan Sahin, Qijing Zhang, Kristina L Bailey, Jill A Poole, Chandrashekhar Charavaryamath

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Tools of the trade: leveraging 3DFrontiers in pharmacology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Denusha ShresthaDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Nyzil MasseyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Sanjana Mahadev BhatDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Tomislav JelesijevićDepartment of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, United States.
Orhan SahinDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, United States.
Qijing ZhangVeterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, United States.
Kristina L BaileyDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Jill A PooleDepartment of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Chandrashekhar CharavaryamathDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Iowa State University · USUniversity of Nebraska Medical Center · USLouisiana State University · US

Funding

Great Plains Center for Agricultural Health (GPCAH)U54OH007548 · OH · UNIVERSITY OF IOWA · PI FETHKE, NATHAN B · 2011 to 2025
$24.6M
Surveillance of Agricultural Injuries in the Central States RegionsU54OH010162 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RAUTIAINEN, RISTO HEIKKI · 2011 to 2025
$23.6M
Resolving Occupational Exposure-Induced Lung DiseaseR01OH012045 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2021 to 2024
$2.3M
NIOSH CDC HHS R01 OH012045NIOSH CDC HHS U54 OH007548NIOSH CDC HHS U54 OH010162
6 · The paper itself

Abstract

Agriculture workers report various respiratory symptoms owing to occupational exposure to organic dust (OD) and various gases. Previously, we demonstrated that pre-exposure to hydrogen sulfide (H

Indexed as

Hydrogen SulfideNF-E2-Related Factor 2AnimalsCytokinesDustKelch-Like ECH-Associated Protein 1Klebsiella pneumoniaeMiceOxidative StressSwineCytokinesDustHydrogen SulfideKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2H2SK. pneumoniaeNrf2organic dustRTA-408

Identifiers

PMID35521223
PMCPMC9062039
OpenAlexW4224236431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.