Evidence map›Paper›PMID 35521214›Full record

ArticleFrontiers in cellular and infection microbiology2022

The Potential Role of Hypochlorhydria in the Development of Duodenal Dysbiosis: A Preliminary Report.

Simone Filardo, Giulia Scalese, Camilla Virili, Stefano Pontone, Marisa Di Pietro, Antonio Covelli, Giorgio Bedetti, Paride Marinelli, Giovanni Bruno, Ilaria Stramazzo and 3 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. OralJournal of oral microbiology · 2025
    Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. In-Silico Functional Metabolic Pathways Associated toInternational journal of molecular sciences · 2022
    Article
  12. Review
  13. Frontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simone FilardoDepartment of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Giulia ScaleseDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.
Camilla ViriliDepartment of Medico-surgical Sciences and Biotechnologies, University of Rome "Sapienza", Latina, Italy.
Stefano PontoneDepartment of Surgical Sciences, University of Rome "Sapienza", Rome, Italy.
Marisa Di PietroDepartment of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Antonio CovelliDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.
Giorgio BedettiDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.
Paride MarinelliDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.
Giovanni BrunoDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.
Ilaria StramazzoDepartment of Medico-surgical Sciences and Biotechnologies, University of Rome "Sapienza", Latina, Italy.
Marco CentanniDepartment of Medico-surgical Sciences and Biotechnologies, University of Rome "Sapienza", Latina, Italy.
Rosa SessaDepartment of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Carola SeveriDepartment of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the role of gastric and duodenal microbiota has acquired increasing importance in the homeostasis of the host, although, to date, most evidence concern the faecal microbiota. Indeed, the gastric, and duodenal microbiota are challenging to study, due to gastric acid, bile, digestive enzymes, and rapid transit time. Specifically, the gastric acid environment may influence their bacterial composition since the acid barrier protects against orally ingested microorganisms and leads to their inactivation before reaching the intestine. The aim of this study was to assess a correlation between intragastric pH and gastric as well as intestinal microbiota of patients with histologic gastric alterations. pH was measured in the gastric juice and the bacterial composition in gastric and duodenal biopsies and faecal samples, was investigated

Indexed as

AchlorhydriaHelicobacter InfectionsHelicobacter pyloriDysbiosisGastric MucosaHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Schronic atrophic gastritisduodenal dysbiosisintragastric pHmetagenomic analysismicrobiotanonatrophic pangastritis

Identifiers

PMID35521214
PMCPMC9062108

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.