Evidence map›Paper›PMID 35520873›Full record

ArticleRSC advances2020

An antibacterial and injectable calcium phosphate scaffold delivering human periodontal ligament stem cells for bone tissue engineering.

Hong Chen, Hui Yang, Michael D Weir, Abraham Schneider, Ke Ren, Negar Homayounfar, Thomas W Oates, Ke Zhang, Jin Liu, Tao Hu and 1 more

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
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  6. Article
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  8. Article
  9. Characterization and Antimicrobial Activity ofAntibiotics (Basel, Switzerland) · 2022
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Hong ChenDepartment of Endodontics, College of Stomatological, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing China.
Hui YangState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University Chengdu China hutao@scu.edu.cn.
Michael D WeirDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School Baltimore MD 21201 USA liujin8511@163.com.
Abraham SchneiderDepartment of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry Baltimore USA.
Ke RenDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, University of Maryland Baltimore MD 21201 USA.
Negar HomayounfarDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School Baltimore MD 21201 USA liujin8511@163.com.
Thomas W OatesDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School Baltimore MD 21201 USA liujin8511@163.com.
Ke ZhangDepartment of Orthodontics, School of Stomatology, Capital Medical University Beijing China tuzizhangke@163.com.ORCID https://orcid.org/0000-0001-7982-5758
Jin LiuDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School Baltimore MD 21201 USA liujin8511@163.com.ORCID https://orcid.org/0000-0001-7613-4476
Tao HuState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University Chengdu China hutao@scu.edu.cn.
Hockin H K XuDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School Baltimore MD 21201 USA liujin8511@163.com.ORCID https://orcid.org/0000-0001-5160-8866
University of Maryland, Baltimore · USSichuan University · CNCapital University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteomyelitis and post-operative infections are major problems in orthopedic, dental and craniofacial surgeries. It is highly desirable for a tissue engineering construct to kill bacteria, while simultaneously delivering stem cells and enhancing cell function and tissue regeneration. The objectives of this study were to: (1) develop a novel injectable calcium phosphate cement (CPC) scaffold containing antibiotic ornidazole (ORZ) while encapsulating human periodontal ligament stem cells (hPDLSCs), and (2) investigate the inhibition efficacy against

Identifiers

PMID35520873
PMCPMC9057516
OpenAlexW3096500020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.