ArticleFrontiers in nutrition2022
The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Previous schistosome infection and the risk of incident hyperuricemia: A prospective cohort study.PLoS neglected tropical diseases · 2026Article
- Effects of adding urinary alkalizer citrate mixture to febuxostat in gout patients with combined-type hyperuricemia and low urine pH: a prospective cohort study.Arthritis research & therapy · 2026Article
- Association between different metabolic obesity phenotypes and hyperuricemia: the modifying role of liver enzymes.Frontiers in public health · 2026Article
- Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.Scientific reports · 2025Article
- Article
- Sustained hyperuricemia disrupts enterohepatic circulation through 12α-hydroxy BA and gut microbiota.Frontiers in microbiology · 2025Article
- A body composition-based clustering study and its association with metabolic phenotypes among the general population in China.Frontiers in nutrition · 2025Article
- Remnant cholesterol elevates hyperuricemia risk in the middle aged and elderly Chinese: a longitudinal study.Scientific reports · 2024Article
- Non-Interventional Weight Changes Are Associated with Alterations in Serum Uric Acid Levels.Journal of clinical medicine · 2024Article
- The role of body mass index on the association between the energy-adjusted dietary inflammatory index and hyperuricemia: a mediation analysis based on NHANES (2007-2016).International journal of obesity (2005) · 2024Article
- Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001-2018.Frontiers in cardiovascular medicine · 2024Article
- Association of resistome abundance with hyperuricaemia in elderly individuals: a metagenomics study.Frontiers in microbiomes · 2024Article
- Association and Interaction between Heavy Metals and Hyperuricemia in a Taiwanese Population.Diagnostics (Basel, Switzerland) · 2023Article
- Chinese familial central precocious puberty with hyperuricemia due to recurrent DLK1 mutation: Case report and review of the literature.Molecular genetics & genomic medicine · 2022Review
- Data-Driven Technology Roadmaps to Identify Potential Technology Opportunities for Hyperuricemia Drugs.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Association between hyperuricemia and metabolic syndrome: A cross-sectional study in Tibetan adults on the Tibetan plateau.Frontiers in endocrinology · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Serum uric acid (UA) not only affects the development of obesity but also alters the metabolic status in obese subjects; thus we investigated the relationship between serum UA and the overweight/obese metabolic phenotypes. Methods: The demographic, biochemical, and hematological data were collected for 12,876 patients undergoing routine physical examination, and 6,912 participants were enrolled in our study. Participants were classified into four obesity metabolic phenotypes according to their BMI and the presence of metabolic syndrome: metabolically healthy overweight/obese (MHOO), metabolically healthy and normal weighted (MHNW), metabolically abnormal and overweight/obese (MAOO), and metabolically abnormal but normal weighted (MANW). Univariate and multivariate logistic regression analysis, stratified analysis, and also interaction analysis were conducted to analyze the relationship between serum UA and obesity metabolic phenotypes. Results: Multivariable logistic regression analysis showed that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes relative to MHNW. After adjusting for the confounding factors, the odds ratios (OR) for individuals with hyperuricemia to be MHOO, MANW, and MAOO phenotypes were 1.86 (1.42-2.45), 2.30 (1.44-3.66), and 3.15 (2.34-4.24), respectively. The ORs for having MHOO, MANW, and MAOO increased 6% [OR: 1.06 (1.05-1.07), Conclusion: In our study, we discovered that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes, and this relationship was independent of sex and age.
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