ArticleRSC advances2019
Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration.
Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
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Who cites it
118 citing papers in PubMed.
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation.Virulence · 2026Article
- In vitro differentiation and phenotypic profiling of Langerhans cell subsets derived from human peripheral blood monocytes.Immunologic research · 2026Article
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.Cancer & metabolism · 2026Article
- Endogenous living adjuvants for cancer vaccination: Concepts, mechanisms, and design principles.Materials today. Bio · 2026Article
- Reduced late endosome/lysosome function promotes SLE through chronic PI3K activity and SHP-1/SHIP-1 defects.JCI insight · 2026Article
- Multi-omics analysis suggests ZDHHC18 as a potential risk factor for clear cell renal cell carcinoma linked to myeloid DC morphology.Discover oncology · 2026Article
- <p>Regulatory networks of HIFs in tumor‑infiltrating immune cells: From molecular mechanisms to therapeutic implications (Review)</p>.International journal of oncology · 2026Review
- Article
- Cutaneous Dendritic Cells: Structure, Function and Immune Role.Biomedicines · 2026Review
- Evaluating nerve dysfunction in Behçet's disease: a study using corneal confocal microscopy and electromyography.International ophthalmology · 2026Article
- Lassa virus circumvents macrophage and dendritic cell antiviral defences in its natural reservoir, the Natal multimammate mouse (Mastomys natalensis).Npj viruses · 2026Article
- Corneal confocal microscopy in fibromyalgia syndrome: small fiber neuropathy, and treatment outcomes.Eye (London, England) · 2026Article
- Deep learning-based segmentation and density estimation of corneal nerves and dendritic cells from In Vivo confocal microscopy images.Scientific reports · 2026Article
- Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.bioRxiv : the preprint server for biology · 2026Article
- Immune cell dynamics and cytokine regulation in cornea and transplantation.Frontiers in immunology · 2026Review
- The interaction between dendritic cells and T follicular helper cells drives inflammatory bowel disease: a review.Frontiers in immunology · 2026Review
- The immune microenvironment of HPV-associated cancers: from viral oncogenesis to immunotherapy response.Frontiers in immunology · 2026Review
- Regulatory dendritic cells and their usefulness in mitigating solid organ transplant rejection.Clinical transplantation and research · 2025Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are antigen-presenting cells that play an important role in connecting the innate and adaptive immunity of the immune system. To mediate innate and adaptive immunity, DCs pass through two stages: immature and mature. The change of phenotype is closely associated with the morphological and functional characteristics of DCs. Understanding these properties of DCs is important in the context of recent efforts on the developments of biomaterials-based cancer vaccine. In this paper, the morphological and phenotypical status of DCs in both stages were compared, and their relationship to the phagocytic and migratory ability of the cells was studied using bone-marrow derived dendritic cells (BMDCs). Immature DCs were of a circular shape and expressed low levels of costimulatory molecules, while mature DCs had longer dendrites and expressed high levels of costimulatory molecules. The phagocytic and migratory ability studied using the polymer bead uptake test and live imaging indicated that immature DCs have a pronounced phagocytic ability compared to mature DCs, while the mature DCs moves faster than immature DCs. These findings could be helpful for understanding the relationship between immature and mature DCs and analyzing initiation of the adaptive immune response by DCs in DC-mediated immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.