Evidence map›Paper›PMID 35520187›Full record

ArticleRSC advances2019

A fluorescent biosensor for cardiac biomarker myoglobin detection based on carbon dots and deoxyribonuclease I-aided target recycling signal amplification.

Jishun Chen, Fengying Ran, Qinhua Chen, Dan Luo, Weidong Ma, Tuo Han, Ceming Wang, Congxia Wang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jishun ChenDepartment of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi 710004 China wcx622@163.com +86-02987679770.
Fengying RanAffiliated Dongfeng Hospital, Hubei University of Medicine Shiyan Hubei 442008 China.
Qinhua ChenAffiliated Dongfeng Hospital, Hubei University of Medicine Shiyan Hubei 442008 China.ORCID 0000-0002-9108-1314
Dan LuoAffiliated Dongfeng Hospital, Hubei University of Medicine Shiyan Hubei 442008 China.
Weidong MaDepartment of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi 710004 China wcx622@163.com +86-02987679770.
Tuo HanDepartment of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi 710004 China wcx622@163.com +86-02987679770.
Ceming WangAffiliated Dongfeng Hospital, Hubei University of Medicine Shiyan Hubei 442008 China.
Congxia WangDepartment of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi 710004 China wcx622@163.com +86-02987679770.ORCID 0000-0001-6262-2276
Hubei University of Medicine · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sensitive biosensor using carbon dots and deoxyribonuclease I-aided target recycling signal amplification has been developed to detect myoglobin (MB), which is an important cardiac biomarker and plays a major role in the diagnosis of acute myocardial infarction (AMI). Here, in the absence of MB, the MB aptamer (Ap) is absorbed on the surface of carbon dots (CDs) through π-π stacking interactions, resulting in quenching of the fluorescent label by forming CD-aptamer complexes. Upon adding MB, the Ap sequences could be specifically recognized by MB, leading to the recovery of quenched fluorescence. Thus, quantitative evaluation of MB concentration has been achieved in a broad range from 50 pg mL

Identifiers

PMID35520187
PMCPMC9060577
OpenAlexW2913704032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.