Evidence map›Paper›PMID 35520044›Full record

ArticleRSC advances2020

A highly sensitive fluorescent immunosensor for sensitive detection of nuclear matrix protein 22 as biomarker for early stage diagnosis of bladder cancer.

Hazha Omar Othman, Foad Salehnia, Neda Fakhri, Rebwar Hassan, Morteza Hosseini, Azad Faizullah, Mohammad Reza Ganjali, Seyed Mohammad Kazem Aghamir

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  15. Current applications of nanomaterials in urinary system tumors.Frontiers in bioengineering and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 5 countries.

Hazha Omar OthmanChemistry Department, College of Science, Salahaddin University-Erbil Iraq.ORCID https://orcid.org/0000-0002-3011-926X
Foad SalehniaCenter of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran Tehran 1417614418 Iran.
Neda FakhriSchool of Chemical Engineering, College of Engineering, University of Tehran Tehran 1417614418 Iran.
Rebwar HassanChemistry Department, College of Science, Salahaddin University-Erbil Iraq.
Morteza HosseiniDepartment of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran Tehran 1417614418 Iran smhosseini@khayam.ut.ac.ir.ORCID https://orcid.org/0000-0002-1492-7443
Azad FaizullahChemistry Department, College of Science, Salahaddin University-Erbil Iraq.
Mohammad Reza GanjaliCenter of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran Tehran 1417614418 Iran.ORCID https://orcid.org/0000-0002-2968-0981
Seyed Mohammad Kazem AghamirUrology Research Center, Tehran University of Medical Sciences Tehran Iran.
University of Tehran · IRDivision of Chemistry · USTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel strategy is reported for highly sensitive, rapid, and selective detection of nuclear matrix protein NMP22 using two-color quantum dots based on fluorescence resonance energy transfer (FRET). Quantum dots (QDs) are highly advantageous for biological imaging and analysis, particularly when combined with (FRET) properties of semiconductor quantum dot (QDs) are ideal for biological analysis to improve sensitivity and accuracy. In this FRET system narrowly dispersed green emitting quantum dot CdTe core is used as a donor and labelled by monoclonal (mAb) antibody, while orange emitting quantum dot CdTe/CdS core shell is used as an accepter and labelled by polyclonal (pAb) antibody. The quantum dots are labelled by antibodies using EDC/NHS as crosslinking agent. Bovine serum albumin (BSA) solution was added to block nonspecific binding sites. The fluorescence intensity of QDs accepter decreased linearly with the increasing concentrations of NMP22 from 2-22 pg mL

Identifiers

PMID35520044
PMCPMC9055858
OpenAlexW3046961838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.