Evidence map›Paper›PMID 35519883›Full record

ArticleRSC advances2019

A label-free immunosensor based on PHEMA/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha fetoprotein.

Ying Liang, Xiaoqing Zhao, Na Wang, Jing Wang, Hou Chen, Liangjiu Bai, Wenxiang Wang

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Electrochemical impedimetric biosensors for food safety.Food science and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ying LiangSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.
Xiaoqing ZhaoSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.
Na WangSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.
Jing WangSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.
Hou ChenSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.ORCID https://orcid.org/0000-0002-0594-5412
Liangjiu BaiSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.ORCID https://orcid.org/0000-0002-4997-627X
Wenxiang WangSchool of Chemistry and Materials Science, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Ludong University Yantai 264025 China chenhou@ldu.edu.cn bailiangjiu@ldu.edu.cn +86-535-6669070 +86-535-6697933.ORCID https://orcid.org/0000-0002-6652-3918
Ludong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An electrochemical immunosensor based on poly(2-hydroxyethyl methacrylate) (PHEMA)/graphene oxide (GO) nanocomposite was designed in a simple way for the ultrasensitive detection of tumor makers (alpha-fetoprotein, AFP as a model). PHEMA with excellent biocompatibility, provides a large number of sites for connecting signal molecules. After modification with signal molecules, the functional PHEMA significantly improved the sensitivity of electrochemical detection. In order to immobilize antibodies, GO was introduced and used to construct a nanocomposite as a substrate. The designed AFP immunosensor showed favorable selectivity and excellent stability. Meanwhile, it has a low detection limit of 0.403 pg mL

Identifiers

PMID35519883
PMCPMC9064557
OpenAlexW2947738126

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.