Evidence map›Paper›PMID 35519619›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Treat Corneal Injury via Autophagy Activation.

Shisi Ma, Jiayang Yin, Lili Hao, Xiao Liu, Qi Shi, Yuyao Diao, Guocheng Yu, Lian Liu, Jiansu Chen, Jingxiang Zhong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Application of autophagy in mesenchymal stem cells.World journal of stem cells · 2024
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Extracellular Vesicles in Corneal Fibrosis/Scarring.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shisi MaDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Jiayang YinDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Lili HaoDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Xiao LiuDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Qi ShiDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Yuyao DiaoDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Guocheng YuDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Lian LiuDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Jiansu ChenDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Jingxiang ZhongDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
First Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal injury (CI) affects corneal integrity and transparency, deteriorating the patient's quality of life. This study aimed to explore the molecular mechanisms by which exosomes secreted from human umbilical cord mesenchymal stem cells (hucMSC-Exos) affect autophagy in human corneal epithelial cells (HCECs) and CI models. We isolated and identified hucMSC-Exos using nanoparticle tracking analysis, transmission electron microscopy, and western blotting. The effects of hucMSC-Exos combined with autophagy regulators on HCECs and CI mice were assessed using cell viability assays, scratch assay, cell cycle assay, apoptosis assay, corneal fluorescein staining, haze grades, pathological examinations, western blotting, and quantitative polymerase chain reaction (qPCR).

Indexed as

apoptosisautophagycorneal injuryexosomeinflammationocular surface regeneration

Identifiers

PMID35519619
PMCPMC9063640
OpenAlexW4223551682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.