ArticleFrontiers in bioengineering and biotechnology2022
A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- In Vivo Brain Deformation in a Sheep Model of Rapid Head Rotation.Annals of biomedical engineering · 2026Article
- From microbleeds to axonal damage: current evidence and future directions.Frontiers in radiology · 2026Review
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- Association Between Cognitive Impairment and Multimodal MRI Markers in Patients with Cerebral Microbleeds: A Retrospective Case-Control Study.International journal of general medicine · 2026Article
- Surface-based versus voxel-based finite element head models: comparative analyses of strain responses.Biomechanics and modeling in mechanobiology · 2025Article
- Computational Modelling of Protected and Unprotected Head Impacts in Rugby.Bioengineering (Basel, Switzerland) · 2025Article
- Modal Analysis of the Human Brain Using Dynamic Mode Decomposition.Bioengineering (Basel, Switzerland) · 2024Article
- When to Pull the Trigger: Conceptual Considerations for Approximating Head Acceleration Events Using Instrumented Mouthguards.Sports medicine (Auckland, N.Z.) · 2024Review
- The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries.Brain : a journal of neurology · 2023Review
- Mechanisms of mechanical load transfer through brain tissue.Scientific reports · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Head Impact Exposure Across Levels of Play in American Football: A Systematic Review of Accelerometer Data.Neurotrauma reportsReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finite Element (FE) models of brain mechanics have improved our understanding of the brain response to rapid mechanical loads that produce traumatic brain injuries. However, these models have rarely incorporated vasculature, which limits their ability to predict the response of vessels to head impacts. To address this shortcoming, here we used high-resolution MRI scans to map the venous system anatomy at a submillimetre resolution. We then used this map to develop an FE model of veins and incorporated it in an anatomically detailed FE model of the brain. The model prediction of brain displacement at different locations was compared to controlled experiments on post-mortem human subject heads, yielding over 3,100 displacement curve comparisons, which showed fair to excellent correlation between them. We then used the model to predict the distribution of axial strains and strain rates in the veins of a rugby player who had small blood deposits in his white matter, known as microbleeds, after sustaining a head collision. We hypothesised that the distribution of axial strain and strain rate in veins can predict the pattern of microbleeds. We reconstructed the head collision using video footage and multi-body dynamics modelling and used the predicted head accelerations to load the FE model of vascular injury. The model predicted large axial strains in veins where microbleeds were detected. A region of interest analysis using white matter tracts showed that the tract group with microbleeds had 95th percentile peak axial strain and strain rate of 0.197 and 64.9 s
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.