Evidence map›Paper›PMID 35519495›Full record

ArticleRSC advances2019

Utilization of metabolic energy in treatment of ocular surface disorders: polyphosphate as an energy source for corneal epithelial cell proliferation.

Adrian Gericke, Xiaohong Wang, Maximilian Ackermann, Meik Neufurth, Matthias Wiens, Heinz C Schröder, Norbert Pfeiffer, Werner E G Müller

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Repair of Corneal Epithelial Defects.Progress in molecular and subcellular biology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Adrian GerickeDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz Langenbeckstrasse 1 55131 Mainz Germany.
Xiaohong WangERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Duesbergweg 6 D-55128 Mainz Germany wmueller@uni-mainz.de wang013@uni-mainz.de +49-6131-39-25243 +49-6131-39-25910.ORCID https://orcid.org/0000-0003-1796-6314
Maximilian AckermannInstitute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Johann Joachim Becher Weg 13 55099 Mainz Germany.
Meik NeufurthERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Duesbergweg 6 D-55128 Mainz Germany wmueller@uni-mainz.de wang013@uni-mainz.de +49-6131-39-25243 +49-6131-39-25910.
Matthias WiensERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Duesbergweg 6 D-55128 Mainz Germany wmueller@uni-mainz.de wang013@uni-mainz.de +49-6131-39-25243 +49-6131-39-25910.
Heinz C SchröderERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Duesbergweg 6 D-55128 Mainz Germany wmueller@uni-mainz.de wang013@uni-mainz.de +49-6131-39-25243 +49-6131-39-25910.
Norbert PfeifferDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz Langenbeckstrasse 1 55131 Mainz Germany.
Werner E G MüllerERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Duesbergweg 6 D-55128 Mainz Germany wmueller@uni-mainz.de wang013@uni-mainz.de +49-6131-39-25243 +49-6131-39-25910.ORCID https://orcid.org/0000-0002-8223-3689
University of Applied Sciences Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired regeneration of the corneal epithelium, as found in many ocular surface diseases, is a major clinical problem in ophthalmology. We hypothesized that corneal epithelial regeneration can be promoted by the physiological, energy-delivering as well as "morphogenetically active" polymer, inorganic polyphosphate (polyP). Corneal limbal explants (diameter, 4 mm) were cultivated on collagen-coated well plates in the absence or presence of polyP (chain length, ∼40 P

Identifiers

PMID35519495
PMCPMC9066647
OpenAlexW2963432337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.