Evidence map›Paper›PMID 35519276›Full record

ArticleBiomedical optics express2022

Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system.

Wihan Kim, Derek Liu, Sangmin Kim, Kumara Ratnayake, Frank Macias-Escriva, Scott Mattison, John S Oghalai, Brian E Applegate

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wihan KimCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0002-4448-7215
Derek LiuCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Sangmin KimDepartment of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Kumara RatnayakeCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Frank Macias-EscrivaCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Scott MattisonDepartment of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
John S OghalaiCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Brian E ApplegateCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0003-2795-5678
University of Southern California · USMitchell Institute · USUniversity of Central Oklahoma · US

Funding

Cochlear mechanics in the mouseR01DC014450 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2015 to 2026
$5.6M
Mechanisms of cochlear synaptopathy after noise or blast traumaR01DC017741 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2020 to 2024
$3.1M
Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomesR01EB027113 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI APPLEGATE, BRIAN E. · 2019 to 2022
$2.6M
Optical coherence tomography for 3D measures of cochlear mechanics in vivoR01DC013774 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2015 to 2019
$2.1M
NIBIB NIH HHS R01 EB027113NIDCD NIH HHS R01 DC013774NIDCD NIH HHS R01 DC014450NIDCD NIH HHS R01 DC017741
6 · The paper itself

Abstract

Optical coherence tomography (OCT) has become an important tool for measuring the vibratory response of the living cochlea. It stands alone in its capacity to measure the intricate motion of the hearing organ through the surrounding otic capsule bone. Nevertheless, as an extension of phase-sensitive OCT, it is only capable of measuring motion along the optical axis. Hence, measurements are 1-D. To overcome this limitation and provide a measure of the 3-D vector of motion in the cochlea, we developed an OCT system with three sample arms in a single interferometer. Taking advantage of the long coherence length of our swept laser, we depth (frequency) encode the three channels. An algorithm to depth decode and coregister the three channels is followed by a coordinate transformation that takes the vibrational data from the experimental coordinate system to Cartesian or spherical polar coordinates. The system was validated using a piezo as a known vibrating element that could be positioned at various angles. The angular measurement on the piezo was shown to have an RMSE of ≤ 0.30° (5.2 mrad) with a standard deviation of the amplitude of ≤ 120 pm. Finally, we demonstrate the system for

Identifiers

PMID35519276
PMCPMC9045890
OpenAlexW4221027759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.