ArticleBiomedical optics express2022
Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- PIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Laser speckle contrast imaging of hepatic microcirculation.Biomedical optics express · 2025Article
- Study on the Correlation Between Renal Blood Perfusion and Kidney Injury in Different Weekly-Aged Type 2 Diabetic Mice.Physiological research · 2024Article
- Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.Nature communications · 2024Article
- Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats.American journal of physiology. Renal physiology · 2024Article
- Exploring the efficacy of laser speckle contrast imaging in the stratified diagnosis of rosacea: a quantitative analysis of facial blood flow dynamics across varied regions.Frontiers in immunology · 2024Article
- In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys.Scientific reports · 2023Article
- Non-contact measurement of neck pulses achieved by imaging micro-motions in the neck skin.Biomedical optics express · 2023Article
- Adaptive window space direction laser speckle contrast imaging to improve vascular visualization.Biomedical optics express · 2023Article
- The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging.Physiological reports · 2023Article
- Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging.eLife · 2022Article
- Cerebral microcirculation disorders after recanalization in acute ischemic stroke: A narrative review.Brain circulationReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laser speckle contrast imaging is a robust and versatile blood flow imaging tool in basic and clinical research for its relatively simple construction and ease of customization. One of its key features is the scalability of the imaged field of view. With minimal changes to the system or analysis, laser speckle contrast imaging allows for high-resolution blood flow imaging through cranial windows or low-resolution perfusion visualization of perfusion over large areas, e.g. in human skin. We further utilize this feature and introduce a multi-scale laser speckle contrast imaging system, which we apply to study vasoreactivity in renal microcirculation. We combine high resolution (small field of view) to segment blood flow in individual vessels with low resolution (large field of view) to monitor global blood flow changes across the renal surface. Furthermore, we compare their performance when analyzing blood flow dynamics potentially associated with a single nephron and show that the previously published approaches, based on low-zoom imaging alone, provide inaccurate results in such applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.