Evidence map›Paper›PMID 35519073›Full record

ArticleRSC advances2020

Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives.

Rintaro Iwata Hara, Reijiro Yoshino, Yohei Nukaga, Yusuke Maeda, Kazuki Sato, Takeshi Wada

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rintaro Iwata HaraFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.ORCID https://orcid.org/0000-0003-2399-3431
Reijiro YoshinoFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.
Yohei NukagaFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.
Yusuke MaedaFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.
Kazuki SatoFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.
Takeshi WadaFaculty of Pharmaceutical Sciences, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan twada@rs.tus.ac.jp.ORCID https://orcid.org/0000-0001-7403-4033
Tokyo University of Science · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphorothioate (PS) modification, where a non-bridging oxygen atom in a phosphodiester linkage is replaced by a sulfur atom, is widely used to improve the properties of nucleic acid drugs. Each PS linkage can be found in two stereoisomers,

Identifiers

PMID35519073
PMCPMC9056737
OpenAlexW3085617707

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.