ArticleMethodsX2022
Development of a USE/d-SPE and targeted DIA-Orbitrap-MS acquisition methodology for the analysis of wastewater-derived organic pollutants in fish tissues and body fluids.
Article in MethodsX, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Chloramphenicol Residue Analysis in Food and Environmental Matrices: Regulatory Framework and Advances in Trace-Level Determination.Molecules (Basel, Switzerland) · 2026Review
- Identifying Novel DNA Adducts in Amphipods and Developing Sample Preparation for Adductomics Using Dispersive Solid-Phase Extraction.Environmental science & technology · 2025Article
- High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage.Environmental science & technology · 2024Review
- Analysis of chemical contaminants in fish using high resolution mass spectrometry - A review.Trends in environmental analytical chemistry · 2024Article
- The methane-oxidizing microbial communities of three maar lakes in tropical monsoon Asia.Frontiers in microbiology · 2024Article
- An effective method for the simultaneous extraction of 173 contaminants of emerging concern in freshwater invasive species and its application.Analytical and bioanalytical chemistry · 2023Article
- HRMS-Targeted-DIA methodology for quantification of wastewater-borne pollutants in surface water.MethodsX · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmaceuticals (PhACs) are partially removed during wastewater treatment and end up in the receiving waters. As a result, aquatic biota is continuously exposed to a wide range of potentially hazardous contaminants such as PhACs. Therefore, fish could be a good bio indicator to give a direct measure of the occurrence of PhACs in the aquatic environment. In this study, a robust analytical method has been optimized and validated for the determination of 81 organic compounds, mainly PhACs, in seven wild fish tissue types (liver, muscle, pancreas, kidney, skin, heart, and brain) and two body fluids (plasma and bile). Solid samples extraction was performed combining a procedure based on bead beating tissue homogenization plus ultrasound extraction followed by dispersive solid-phase extraction (dSPE) clean-up using zirconia and C18 sorbents for solid matrices, whereas bile and plasma were diluted. The key aspects of this method are: • The method facilitated the simultaneous extraction of 81 PhACs of a wide range of polarity (logP from -4.9 to 5.6) in tissues with variable lipid content. • The validation was performed using
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Registered trials
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