Evidence map›Paper›PMID 35518870›Full record

ArticleRSC advances2019

Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols.

Takafumi Hashimoto, Daiki Nozawa, Katsuyuki Mukai, Akinobu Matsuyama, Kouji Kuramochi, Toshiki Furuya

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Optimized Bioconversion of Naringenin to Hesperetin inEngineering in life sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Regioselective One-Pot Synthesis of Hydroxy-(Frontiers in bioengineering and biotechnology · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Takafumi HashimotoDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan tfuruya@rs.tus.ac.jp.
Daiki NozawaDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan tfuruya@rs.tus.ac.jp.
Katsuyuki MukaiDaicel Corporation 2-18-1 Konan, Minato-ku Tokyo 108-8230 Japan.
Akinobu MatsuyamaDaicel Corporation 2-18-1 Konan, Minato-ku Tokyo 108-8230 Japan.
Kouji KuramochiDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan tfuruya@rs.tus.ac.jp.
Toshiki FuruyaDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan tfuruya@rs.tus.ac.jp.ORCID https://orcid.org/0000-0002-0690-5463
Tokyo University of Science · JPDaicel (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monooxygenases exhibiting high activity and differing regioselectivity for the dietary isoflavone metabolite equol were discovered among enzymes in the HpaBC family by a genome mining approach. These enzymes enabled the one-step product-selective synthesis of 3'- and 6-hydroxyequols from equol and molecular oxygen.

Identifiers

PMID35518870
PMCPMC9066559
OpenAlexW2957584543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.