ArticleRSC advances2020
Microdroplet synthesis of azo compounds with simple microfluidics-based pH control.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Chemistry-informed Bayesian control and policy distillation for autonomous pH adjustment in diverse chemical systems.Chemical science · 2026Article
- Resonant oscillation of droplets under an alternating electric field to enhance solute diffusion.Scientific reports · 2024Article
- Towards Industrially Important Applications of Enhanced Organic Reactions by Microfluidic Systems.Molecules (Basel, Switzerland) · 2024Review
- Controlling Microdroplet Inner Rotation by Parallel Carrier Flow of Sesame and Silicone Oils.Micromachines · 2021Article
- Efficient Generation of Microdroplets Using Tail Breakup Induced with Multi-Branch Channels.Molecules (Basel, Switzerland) · 2021Article
- Microdroplet synthesis of azo compounds with simple microfluidics-based pH control.RSC advances · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional solution-phase synthesis of azo compounds is complicated by the need for precise pH and temperature control, high concentrations of pH control reagents, and by-product removal. In this work, we exploited the advantages of microdroplet chemistry to realize the simple and highly efficient synthesis of an azo compound using microfluidics-based pH control. Owing to the small size of microdroplets, heat exchange between a microdroplet and its environment is extremely fast. Furthermore, chemical reactions in microdroplets occur rapidly due to the short diffusion distance and vortex flow. Formation of the azo compound reached completion in less than 3 s at room temperature, compared with 1 h at 0 °C under conventional conditions. pH control was simple, and the pH control reagent concentration could be reduced to less than one-tenth of that used in the conventional method. No by-products were generated, and thus this procedure did not require a recrystallization step. The time course of the chemical reaction was elucidated by observing the growth of azo compound microcrystals in droplets at various locations along the channel corresponding to different mixing times.
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Registered trials
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