Evidence map›Paper›PMID 35518386›Full record

ArticleRSC advances2020

Insight into N-terminal localization and dynamics of engineered virus-like particles.

Daan F M Vervoort, Chiara Pretto, Jan C M van Hest

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Daan F M VervoortEindhoven University of Technology, Institute for Complex Molecular Systems PO Box 513 (STO 3.41) 5600 MB Eindhoven The Netherlands j.c.m.v.hest@tue.nl.
Chiara PrettoEindhoven University of Technology, Institute for Complex Molecular Systems PO Box 513 (STO 3.41) 5600 MB Eindhoven The Netherlands j.c.m.v.hest@tue.nl.
Jan C M van HestEindhoven University of Technology, Institute for Complex Molecular Systems PO Box 513 (STO 3.41) 5600 MB Eindhoven The Netherlands j.c.m.v.hest@tue.nl.ORCID https://orcid.org/0000-0001-7973-2404
Institute for Complex Systems · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-like particles composed of the cowpea chlorotic mottle virus (CCMV) capsid protein (CP) have been extensively studied as carrier systems in nanoscience. One well-established method to improve their stability under physiological conditions is to fuse a stimulus-responsive elastin-like polypeptide (ELP) to the N-terminus of the CPs. Even though the N-terminus should in principle be localized in the inner cavity of the protein cage, studies on the native CCMV revealed its accessibility on the particle surface. We verified that such phenomenon also applies to ELP-CCMVs, by exploiting the covalent functionalization of the CP N-terminal domain

Identifiers

PMID35518386
PMCPMC9057346
OpenAlexW3094157863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.